PMID: 20650146Oct 1, 1995Paper

Inhibition of iron toxicity in rat hepatocyte culture by natural phenolic compounds

Toxicology in Vitro : an International Journal Published in Association with BIBRA
H ChimiJ Cillard

Abstract

Iron supplementation of adult rat hepatocyte culture induced a cytotoxic effect as shown by an increase of lipid peroxidation. The antioxidant activity of some natural phenolic compounds from olive oil (caffeic acid, oleuropein, tyrosol and hydroxytyrosol) has been investigated on this iron-loaded hepatocyte culture model. These compounds greatly reduced malondialdehyde production which was used as a marker for iron-induced lipid peroxidation. This reduction was concentration-dependent of phenolic compound (in the range of 20-100 mum). Moreover, it was not significantly different from one tested compound to another. To clarify the antioxidant mechanism of these compounds, their free radical scavenging activity has been tested in a cell-free experimental model using spin trapping-electron paramagnetic resonance spectroscopy. The four tested compounds were able to scavenge hydroxyl and lipid radicals. They exhibited various efficiency towards hydroxyl radical whereas they presented the same order of reactivity towards lipid radicals. Moreover, only caffeic acid and oleuropein could scavenge Superoxide anion. Therefore, the reactivity of the phenolic compounds towards these reactive oxygen species provided an insight into their an...Continue Reading

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Citations

Feb 5, 1999·Biochemical Pharmacology·R de la PuertaJ R Hoult
Jun 1, 2000·Nutrition Research Reviews·G G DuthieJ A Kyle
Jul 7, 2007·Natural Product Research·Nongporn Hutadilok-TowatanaWilawan Mahabusarakam
Apr 1, 1998·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E L Ghisalberti
Jun 19, 2008·Journal of Biochemical and Molecular Toxicology·Nagarajan DevipriyaVenugopal P Menon
May 18, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Dmitriy N AtochinMark B Plotnikov
May 14, 2005·Fitoterapia·Joaquín AltarejosAdolfo Sánchez
Apr 2, 2005·Luminescence : the Journal of Biological and Chemical Luminescence·Irena KrukAleksandra Kładna

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