PMID: 3749605Jul 1, 1986Paper

Inhibition of isoproterenol positive atrial chronotropic effect by methylmethacrylate polymer and monomer

Research Communications in Chemical Pathology and Pharmacology
D W WillisC K Born

Abstract

Atria from rats exposed in vivo to methylmethacrylate polymer or monomer were superfused and chronotropic responses to isoproterenol determined. Control and polymer-exposed atria superfused with oxygen-saturated buffer yielded dose-response curves which were essentially identical with regard to maximal increase and potency of isoproterenol. Control atria superfused with buffer containing 70% of possible oxygen saturation showed a 10-fold decrease in isoproterenol potency and a maximal effect approximately 75-80% that of fully oxygenated atria. Atria exposed to methylmethacrylate polymer and superfused with 70% oxygen saturated buffer showed a 100-fold decrease in isoproterenol potency and a maximal effect approximately 25% that of fully oxygenated control atria. Exposure of rats to methylmethacrylate monomer in vivo resulted in complete abolition of the chronotropic response to isoproterenol in atria superfused with 70% oxygen saturated media.

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