PMID: 6411113Aug 1, 1983Paper

Inhibition of lactation by cyclofenil and bromocriptine

British Journal of Obstetrics and Gynaecology
G Thorbert, M Akerlund

Abstract

In a double blind controlled study of the inhibition of lactation 13 women received 300 mg of cyclofenil and 11 women 2.5 mg of bromocriptine twice daily for 14 days. Lactation was effectively inhibited by both drugs, but with bromocriptine there was a significantly higher frequency of relapse. The plasma concentration of prolactin, which decreased rapidly with bromocriptine, returned to the pretreatment level the day after drug treatment stopped, but with cyclofenil it remained low. Plasma oestradiol followed a similar pattern. Plasma FSH increased more rapidly with bromocriptine than with cyclofenil. There was no significant difference between the treatment groups at any stage for haematology, coagulation or liver function tests. The more sustained effect of cyclofenil on prolactin secretion with a reduced frequency of relapse, and the lower oestradiol level, which might indicate a reduced risk of thromboembolism, suggest that this drug has some advantage over bromocriptine in the inhibition of postpartum lactation.

References

Oct 1, 1978·British Journal of Clinical Pharmacology·P PriceJ Rosenthaler
Dec 1, 1968·The Journal of Obstetrics and Gynaecology of the British Commonwealth·A C Turnbull
Feb 1, 1981·European Journal of Clinical Pharmacology·L Borgström

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Citations

Oct 1, 1984·British Journal of Obstetrics and Gynaecology·E Schwarzenau, W Völker
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Olufemi T Oladapo, Bukola Fawole

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