Inhibition of LDL oxidation by a new estradiol receptor modulator compound LY-139478, comparative effect with other steroids

Atherosclerosis
A K Rattan, Y Arad

Abstract

Oxidation of low-density lipoprotein (LDL) is postulated to be essential for the development of atherosclerosis. LY-139478 is a new non-steroidal potent estrogen analog, but its effects on in vitro LDL oxidation have not been completely elucidated. We investigated the ability of LY-139478 to inhibit in vitro copper sulfate-mediated LDL oxidation using several methods, including conjugated diene (CD) accumulation, relative electrophoretic mobility on agarose gel, thiobarbituric acid-reactive substances (TBARS) assay, and superoxide anions scavenging activity. The antioxidative potential of LY-139478 was compared to testosterone (T), 17-alpha-estradiol (17alphaE), 17-beta-estradiol (17betaE), dehydroepiandrosterone (D), and dehydroepiandrosterone-3-sulfate (DS). LY-139478 was superior to 17alphaE and 17betaE in prolonging the lag phase and decreasing the slope and peak concentration of the conjugated diene accumulation, decreasing the rate of migration of LDL on agarose gel electrophoresis, and inhibiting the production of melonyldialdehyde (MDA) in the TBARS assay. T, D and DS were ineffective in all three assays. It was previously shown that when native LDL is oxidized by previously oxidized LDL (secondary oxidation) the lag ph...Continue Reading

References

Oct 1, 1992·Metabolism: Clinical and Experimental·V A Rifici, A K Khachadurian
Jul 25, 1992·BMJ : British Medical Journal·J A DewarR A Wood
Sep 12, 1991·The New England Journal of Medicine·M J StampferC H Hennekens
Jul 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·E Barrett-Connor, M Laakso
Apr 1, 1990·The Journal of Clinical Endocrinology and Metabolism·J D BagdadeW Ryan
Mar 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·Y AradH N Ginsberg
Jan 1, 1989·Free Radical Research Communications·H EsterbauerM Rotheneder
Dec 11, 1986·The New England Journal of Medicine·E Barrett-ConnorS S Yen
Apr 30, 1987·The New England Journal of Medicine·G A ColditzC H Hennekens
Oct 22, 1987·The New England Journal of Medicine·J Mohle-Boetani, A Whittemore
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·U P SteinbrecherD Steinberg
Nov 1, 1995·Progress in Cardiovascular Diseases·T B ClarksonK P Klein
Aug 1, 1995·Free Radical Research·E SchnitzerD Lichtenberg
Oct 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·V SalomaaG Myllylä
May 1, 1995·American Journal of Epidemiology·C RodriguezC W Heath
Jun 15, 1995·The New England Journal of Medicine·G A ColditzF E Speizer
Nov 1, 1994·European Journal of Clinical Investigation·M J van der MoorenR Rolland
Dec 15, 1994·Annals of Internal Medicine·E H LiebermanM A Creager
Apr 1, 1996·Metabolism: Clinical and Experimental·M TangM T Subbiah
Jun 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M SatoH U Bryant
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·P A BourassaR J Aiello
Aug 23, 1996·Atherosclerosis·P AlexandersenC Christiansen
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON

❮ Previous
Next ❯

Citations

Dec 1, 2010·Archives of Pharmacal Research·Hyoung Jin KimSoon Ha Kim
Feb 7, 2001·Trends in Endocrinology and Metabolism : TEM·E Barrett-ConnorP W Anderson
Nov 20, 2002·Menopause : the Journal of the North American Menopause Society·Carlos HermenegildoAntonio Cano
Jun 10, 2004·Journal of Women's Health·Ulrike ReschHelmut Sinzinger
Jul 5, 2005·Expert Opinion on Investigational Drugs·P Holvoet
Apr 17, 2001·American Journal of Obstetrics and Gynecology·R A Wild, S E Reis
Oct 25, 2002·Cardiovascular Drug Reviews·Wolfgang Weidemann, Hartmut Hanke
Jun 22, 2000·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·E Windler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.