Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension

Journal of Hypertension
B HocherY M Pinto

Abstract

Growth factors such as transforming growth factor-beta (TGF beta) are believed to have an essential role in cardiac fibrosis. Tranilast (N(3,4-dimethoxycinnamoyl) anthranilic acid) attenuates the increased expression of TGF beta mRNA in vitro. To investigate whether tranilast reduces cardiac fibrosis in rats with two-kidney, one-clip (2K1C) renovascular hypertension. In addition, we tested the in-vitro effects of tranilast on cardiac myocytes and non-myocyte cells. We analysed hearts from four groups of rats: sham-operated controls; rats with 2K1C renovascular hypertension; rats with 2K1C renovascular hypertension treated for 12 weeks with the angiotensin converting enzyme (ACE) inhibitor, quinapril (6 mg/kg per day); rats with 2K1C renovascular hypertension treated for 12 weeks with tranilast (400 mg/kg per day). Systolic blood pressure was reduced after quinapril treatment. Tranilast did not alter blood pressure (2K1C: 223 +/- 19 mmHg; 2K1C + quinapril: 149 +/- 15 mmHg (P < 0.01 compared with 2K1C); 2K1C + tranilast: 204 +/- 32 mmHg). Left ventricular weight was likewise reduced significantly by quinapril, but not significantly by tranilast (2K1C: 1.52 +/- 0.2 g; 2K1C + quinapril: 1.26 +/- 0.18 g (P < 0.05 compared with 2K1C)...Continue Reading

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Citations

Jul 8, 2003·Current Hypertension Reports·Rubin ZhangEfrain Reisin
May 17, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Federico FranchiMartin Rodriguez-Porcel
Oct 1, 2010·Cardiovascular Research·Esther E Creemers, Yigal M Pinto
Jul 25, 2009·American Journal of Physiology. Renal Physiology·Jingfei ChengJoseph P Grande
Jun 2, 2005·Expert Opinion on Investigational Drugs·Lars GullestadPål Aukrust
Sep 10, 2014·Journal of the Neurological Sciences·Mitsuru HanadaYukihiro Matsuyama
Sep 3, 2011·Cardiovascular Therapeutics·Amanda J EdgleyDarren J Kelly
Aug 12, 2014·Cardiovascular Research·Anke J TijsenEsther E Creemers
Aug 29, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Gérald J Prud'homme
Jul 11, 2018·Heart Failure Reviews·Emiri TarbitRoselyn B Rose'Meyer
Apr 13, 2004·Journal of Hypertension·Saman RasoulNour-Eddine Rhaleb
Mar 27, 2020·Frontiers in Cardiovascular Medicine·Warisara ParichatikanondHitoshi Kurose
Mar 29, 2005·Molecular and Cellular Biochemistry·María Francisca García-SauraJuan Duarte
Mar 26, 2005·Canadian Journal of Physiology and Pharmacology·Sheila A Doggrell, Janet C Wanstall
Dec 15, 2020·Life Sciences·Savalan Babapoor-FarrokhranSumeet K Mainigi

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