Inhibition of lipid peroxidation by N-acetylserotonin and its role in retinal physiology

Biochemical and Biophysical Research Communications
B LongoniP L Marchiafava

Abstract

N-Acetylserotonin (NAS) inhibits the peroxidation of linoleic acid induced by a water-soluble initiator, 2,2'-azobis(2-amidinopropane) (ABAP). Lipid peroxidation was detected by the formation of conjugated dienes, monitored spectrophotometrically at 236 nm. N-Acetylserotonin, at concentrations ranging from 200 nM to 20 microM, reduced the rate of ABAP-initiated lipid peroxidation in a concentration-dependent manner. The results of NAS-inhibited lipid peroxidation are compared to the antioxidant activities of melatonin, vitamin E, and a water-soluble vitamin E analog, Trolox. It is suggested that NAS acts as a physiological antioxidant in retinal photoreceptor cells.

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Citations

May 1, 2004·Journal of Medicinal Food·Do Yu SoungHae Young Chung
May 8, 1999·Journal of Pineal Research·P L Marchiafava, B Longoni
Feb 18, 2010·International Journal of Molecular Sciences·Sergio Millán-PlanoJoaquín J García
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Jun 12, 2018·Journal of Pineal Research·Annia Galano, Russel J Reiter
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Jun 17, 2015·The Journal of Physical Chemistry. B·Ruslán Álvarez-DidukRussel J Reiter

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