Abstract
To test the effect of mammary blood flow on net uptakes of milk precursors by the mammary glands, inhibitors of nitric oxide synthase (NOS) and cyclooxygenase (COX) were infused into the mammary circulation of 4 lactating cows. Inhibitors were infused in a 4×4 Latin square design, where treatments were infusion for 1 h of saline, NOS inhibitor (Nω-nitro-l-arginine methyl ester hydrochloride), COX inhibitor (indomethacin), or both NOS + COX inhibitors into one external iliac artery. Para-aminohippuric acid was also infused to allow for estimation of iliac plasma flow (IPF), of which approximately 80% flows to the mammary glands. Blood samples were collected before, during, and after inhibitor infusion from the contralateral external iliac artery and ipsilateral mammary vein. Inhibition of COX and NOS each produced a decrease in IPF, although the NOS effect was smaller and IPF continued to be depressed throughout the recovery period. The combination of COX and NOS inhibition produced a 50% depression in IPF and there was no carryover into the recovery period. Treatments that depressed IPF also increased arterial concentrations of acetate, β-hydroxybutyrate (BHBA), and glucose. Similarly, arteriovenous differences of acetate, BHBA...Continue Reading
References
May 1, 1992·The Journal of Dairy Research·S TesseraudC Champredon
Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·K ChristensenN Jarløv
Jul 11, 1968·The American Journal of Physiology·D S KronfeldC F Ramberg
Aug 1, 1995·The Journal of Dairy Research·J P Cant, B W McBride
Jun 1, 1995·The Journal of Endocrinology·M O NielsenR B Heap
Jul 1, 1994·The Journal of Endocrinology·C G ProsserP D Gluckman
Mar 1, 1993·Journal of Dairy Science·J P CantR L Baldwin
Oct 1, 1995·Journal of Dairy Science·J Guinard, H Rulquin
Oct 1, 1996·Metabolism: Clinical and Experimental·A J KrentzD S Schade
Mar 20, 1998·The British Journal of Nutrition·M D HaniganN E Smith
May 3, 2000·Journal of Dairy Science·B J BequetteJ C MacRae
Jun 7, 2000·The Journal of Dairy Research·G G CherepanovJ P Cant
Nov 1, 2001·Journal of Animal Physiology and Animal Nutrition·C H KimD G Chamberlain
Apr 13, 2002·Journal of Dairy Science·J P CantN G Purdie
Nov 6, 2002·Journal of Dairy Science·S RigoutH Rulquin
Jul 3, 2003·Journal of Dairy Science·P Lacasse, C G Prosser
Apr 1, 1954·The Journal of Clinical Investigation·R ANDRESJ L LILIENTHAL
Jun 1, 1954·Journal of Applied Physiology·P MEIER, K L ZIERLER
Oct 1, 1960·The Journal of Physiology·J L LINZELL
Nov 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Naris Thengchaisri, Lih Kuo
Nov 3, 2004·Domestic Animal Endocrinology·M O NielsenJ Nørgaard
May 21, 2005·Journal of Applied Physiology·Fulong QiaoJohn P Cant
Mar 30, 2006·The Journal of Dairy Research·Henri Rulquin, Pawel M Pisulewski
Dec 22, 2007·Journal of Dairy Science·N G PurdieJ P Cant
Jan 12, 2010·Journal of Dairy Science·B J Bequette, L W Douglass
Jul 16, 2010·Journal of Dairy Science·A G RiusM D Hanigan
Feb 11, 2014·Journal of Dairy Science·S R L CieslarJ P Cant
Dec 31, 2014·Journal of Dairy Science·C LeeC Parys
Citations
Feb 27, 2018·Journal of Dairy Science·Richelle V CurtisJohn P Cant
Aug 2, 2017·Journal of the Science of Food and Agriculture·Jie CaiJianxin Liu
Nov 9, 2018·Frontiers in Physiology·Jie CaiDi-Ming Wang
Dec 10, 2020·Journal of Animal Science and Biotechnology·Virginia L Pszczolkowski, Sebastian I Arriola Apelo
Jan 19, 2021·Journal of Dairy Science·X HuangM D Hanigan
Dec 7, 2021·Journal of Animal Science and Biotechnology·Zongjun LiJunhu Yao