PMID: 8594885Dec 1, 1995Paper

Inhibition of local nitric oxide synthase increases homeostatic efficiency of tubuloglomerular feedback

The American Journal of Physiology
Volker Vallon, S C Thomson

Abstract

Nephron filtration rate (SNGFR) and proximal tubular reabsorption are coordinated by the processes of tubuloglomerular feedback (TGF) and glomerulotubular balance (GTB). We examined the role of nitric oxide (NO) in TGF and GTB, by delivering the NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA) into late proximal nephrons by micropuncture in Inactin-anesthetized euvolemic rats. First, we determined the dependence of SNGFR on late proximal tubular flow rate (VLP) during orthograde microperfusion of Henle's loop downstream from an obstructing wax block (open-loop microperfusion). Second, we examined the homeostatic efficiency of the TGF-GTB system, (i.e., its ability to stabilize VLP) by perturbing VLP in free-flowing nephrons, while using a noninvasive optical technique to measure flow immediately upstream from the perturbation (closed-loop perturbation). Third, we tested whether L-NMMA could alter the afferent signal to TGF by changing the relationship between VLP and the flow rate (VED) or ionic content (CED) of early distal tubular fluid during open-loop microperfusion. During open-loop microperfusion, L-NMMA decreased SNGFR at VLP between 10 and 40 nl/min but did not alter the relationship between VLP and VED or CED. ...Continue Reading

Citations

Sep 23, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Armin Just
Jul 4, 2006·Physiological Reviews·Volker VallonHartmut Osswald
Feb 10, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A PaliegeS Bachmann
Nov 22, 2013·American Journal of Physiology. Renal Physiology·Prabhleen Singh, Scott C Thomson
Jul 25, 2000·Journal of Applied Physiology·N D VaziriR E Purdy
Nov 1, 2018·American Journal of Physiology. Renal Physiology·Scott C Thomson
Jun 24, 2004·American Journal of Physiology. Renal Physiology·Scott C ThomsonFrancis B Gabbai
Oct 20, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alemayehu H JufarRoger G Evans
Jul 20, 2001·Journal of the American Society of Nephrology : JASN·Volker VallonJürgen Schnermann

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