Inhibition of lung tumor development by berry extracts in mice exposed to cigarette smoke

International Journal of Cancer. Journal International Du Cancer
R B BalanskyS De Flora

Abstract

Cigarette smoke (CS) and dietary factors play a major role in cancer epidemiology. At the same time, however, the diet is the richest source of anticancer agents. Berries possess a broad array of health protective properties and were found to attenuate the yield of tumors induced by individual carcinogens in the rodent digestive tract and mammary gland but failed to prevent lung tumors induced by typical CS components in mice. We exposed whole-body Swiss ICR mice to mainstream CS, starting at birth and continuing daily for 4 months. Aqueous extracts of black chokeberry and strawberry were given as the only source of drinking water, starting after weaning and continuing for 7 months, thus mimicking an intervention in current smokers. In the absence of berries, CS caused a loss of body weight, induced early cytogenetical damage in circulating erythrocytes and histopathological alterations in lung (emphysema, blood vessel proliferation, alveolar epithelial hyperplasia and adenomas), liver (parenchymal degeneration) and urinary bladder (epithelial hyperplasia). Both berry extracts inhibited the CS-related body weight loss, cytogenetical damage, liver degeneration, pulmonary emphysema and lung adenomas. Protective effects were more ...Continue Reading

References

May 1, 1987·Mutation Research·R M BalanskyZ I Mircheva
Jan 12, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·G D StonerM A Morse
Jul 4, 2002·Nutrition and Cancer·E Schmitt, H Stopper
Sep 25, 2002·Life Sciences·Emi OsawaHisahiko Sekihara
Jun 26, 2004·Clinical Lung Cancer·James Gasperino, William N Rom
Jun 28, 2006·Nutrition and Cancer·Geeta LalaBernadene A Magnuson
Jun 28, 2006·Nutrition and Cancer·Harri Vainio, Elisabete Weiderpass
Feb 27, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J BoatengC B Chawan
May 4, 2007·Nutrition and Cancer·Carlos A Gonzalez, Elio Riboli
May 25, 2007·Carcinogenesis·Roumen BalanskySilvio De Flora
Jun 19, 2007·Seminars in Cancer Biology·Gary D StonerJohn F Lechner
Jan 24, 2008·Journal of Agricultural and Food Chemistry·Navindra P Seeram
Apr 30, 2008·Nutrition and Cancer·Harini S AiyerRamesh C Gupta
Jun 12, 2008·Carcinogenesis·Gary David StonerBruce Cordell Casto
Jan 14, 2009·Cancer Prevention Research·Li-Shu WangGary D Stoner
Mar 19, 2009·Cancer Chemotherapy and Pharmacology·Sarah ThomassetAndreas J Gescher
May 22, 2009·Carcinogenesis·Roumen BalanskySilvio De Flora
Jul 9, 2009·Cancer Prevention Research·Elena P Moiseeva, Margaret M Manson
Oct 10, 2009·International Journal of Cancer. Journal International Du Cancer·Roumen BalanskySilvio De Flora
Mar 17, 2010·Pharmaceutical Research·Gary D StonerA Douglas Kinghorn
Sep 17, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Isabelle SoerjomataramEsther de Vries

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Citations

Jul 24, 2014·Carcinogenesis·Roumen BalanskySilvio De Flora
Jan 5, 2016·Trends in Pharmacological Sciences·Silvio De FloraRoumen Balansky
Mar 22, 2014·Journal of Agricultural and Food Chemistry·Farrukh AqilRamesh C Gupta
Sep 12, 2015·Critical Reviews in Food Science and Nutrition·Tamara Y Forbes-HernandezMaurizio Battino
Mar 25, 2015·Food & Function·Francesca GiampieriMaurizio Battino
May 31, 2014·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Silvio De FloraRoumen Balansky
Aug 23, 2016·International Journal of Molecular Sciences·Madumani AmararathnaH P Vasantha Rupasinghe
Oct 25, 2016·Antioxidants·Aleksandra S KristoAngelos K Sikalidis
Jun 16, 2017·Annals of the New York Academy of Sciences·Francesca GiampieriMaurizio Battino
Jan 16, 2018·Oxidative Medicine and Cellular Longevity·Ahmad HusariMarwan El Sabban
May 17, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Mukesh Verma
Jul 6, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Roumen BalanskySilvio De Flora
Aug 28, 2021·Cells·Antonio Rivas-DomínguezManuel Luis Orta

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