Inhibition of lymphocyte capping and transformation by propranolol and related compounds

British Journal of Pharmacology
B H AndertonS Sprake

Abstract

1 The effects of propranolol on phytohaemagglutinin (PHA)-induced transformation of murine T lymphocytes and capping of anti-IgG on the surface of murine B lymphocytes have been examined. 2 A 50% inhibition of transformation was observed with 10(-5) M propranolol, whereas a higher concentration, of the order of 10(-3) M propranolol was required to inhibit capping by 50%. The (+)-and (-)-isomers of propranolol proved equipotent in these respects, and the relative potencies of selected analogues of propranolol (alprenolol, oxprenolol, metoprolol, practolol, and sotalol) coincided with their potencies as membrane stabilizers; however, lymphocyte transformation was consistently more sensitive than capping. 3 Similar effects were also seen with quinidine, chlorpromazine and lignocaine, and it was concluded that the inhibition of both lymphocyte functions was due to the membrane stabilizing actions of propranolol.

References

Sep 1, 1976·Clinical Immunology and Immunopathology·G F Schreiner, E R Unanue
Oct 1, 1974·The Journal of Experimental Medicine·F V Chisari, T S Edgington
Jun 30, 1971·Nature: New Biology·S Roth, P Seeman
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Citations

Feb 1, 1982·The Journal of Pharmacy and Pharmacology·D G Trist, M Weatherall
Aug 1, 1995·Immunopharmacology and Immunotoxicology·S InH Benoist

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