Inhibition of lymphocyte IL2-receptor expression by factor VIII concentrate: a possible cause of immunosuppression in haemophiliacs

British Journal of Haematology
C R HayM Duggan-Keen

Abstract

Factor VIII concentrate inhibits T-cell function in vitro and in vivo. The mechanisms underlying the phenomenon were investigated. Factor VIII concentrate has a direct effect on lymphocytes, uninfluenced by haemophilic monocyte dysfunction, since it inhibited lymphocyte transformation with phorbol myristate acetate, a reaction unaffected by monocyte depletion. Inhibition of lymphocyte transformation by factor VIII concentrate is not corrected by the addition of exogenous IL2, suggesting that it does not inhibit lymphocyte function by suppression of IL2 secretion alone. Factor VIII concentrate causes profound inhibition of IL2-receptor expression (CD25); with an 89% reduction in CD25-positive CD4 cells and a 50% reduction in CD25-antigen molecules per cell. CD8 lymphocytes are similarly affected. Smaller reductions in CD71 and HLA-DR expression are also observed. Down modulation of CD25-antigen may explain the reduced IL2 secretion observed by others, and may be an important cause of immunodeficiency in HIV-seronegative haemophiliacs.

References

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Sep 1, 1985·British Journal of Haematology·E H MoffatR G Newcombe
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Citations

Sep 1, 1992·British Journal of Haematology·A BatchelorC A Ludlam
Nov 1, 1992·British Journal of Haematology·M WadhwaR Thorpe
Dec 23, 2011·ISRN Oncology·Ettie Piura, Benjamin Piura
Sep 1, 1992·Blood Reviews·M Winter
Dec 3, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·A B GrossetG M Rodgers
Jan 1, 1996·Haemophilia : the Official Journal of the World Federation of Hemophilia·C R HayG Savidge
Apr 1, 1996·Haemophilia : the Official Journal of the World Federation of Hemophilia·D P AllersmaE Briët

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