Inhibition of lymphocyte-induced angiogenesis by free radical scavengers

Free Radical Biology & Medicine
M MonteE S de Lustig

Abstract

Solid tumors induce an angiogenic response by the host blood vessels to form a new vascular network for the supply of fresh nutrients and oxygen responsible for tumor growth. Furthermore, tumor growth and metastatic spread is abrogated or markedly reduced in the absence of neovascularization. Spleen T lymphocytes from tumor-bearing mice elicit a strong neovascular response. It is well known that certain T cell responses require the presence of active oxygen radicals. Because these metabolites are produced during tumor growth, we studied whether oxygen free radicals play a role in the angiogenesis induction by lymphocytes. In this study, we demonstrated that the administration of a free radical scavenger (EGb-761) to tumor-bearing mice, blocked the angiogenic response and decreased the lung metastatic incidence. On the other hand, when normal lymphocytes were incubated with the xanthine-xanthine oxidase system (X-XO), a known superoxide anion generator, this elicited a dose-response positive angiogenic reaction in normal recipient mice. No angiogenic response was observed in the absence of X-XO, or when EGb-761 or superoxide dismutase (SOD) plus catalase (CAT) were added to the incubation medium. These results suggest that free ...Continue Reading

References

Jun 1, 1990·Biochimica Et Biophysica Acta·C H Blood, B R Zetter
May 1, 1985·Transplantation·L E DavelE S de Lustig
Jan 1, 1989·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·A G Fuchs, E S de Lustig
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·A BoverisC G Fraga

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Citations

Jan 1, 1997·Lasers in Surgery and Medicine·K A KadipasaogluO H Frazier
May 11, 2000·Lasers in Surgery and Medicine·A D AgaibyM Dyson
Nov 16, 2001·Biochemical and Biophysical Research Communications·M ShimamuraS Yamamoto
Jan 1, 1996·Breast Cancer Research and Treatment·D F AlonsoE Bal de Kier Joffé
Apr 10, 1999·The Annals of Thoracic Surgery·R AgarwalK M Cherian
Jun 5, 2002·Mechanisms of Ageing and Development·Srinivasan ThyagaRajan, David L Felten
Oct 11, 2002·Free Radical Biology & Medicine·Nilanjana Maulik, Dipak K Das
Apr 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M MonteE Sacerdote de Lustig
Jan 14, 2000·Journal of Anatomy·A D Agaiby, M Dyson
Dec 10, 2002·Antioxidants & Redox Signaling·Nilanjana Maulik
Aug 2, 2007·Antioxidants & Redox Signaling·Kazuhiro IchikawaHideo Utsumi
Jun 27, 2007·Cornea·Mesut ErdurmusRemzi Karadag
Oct 1, 1996·The Journal of Clinical Investigation·M KurokiA P Adamis
May 28, 2013·Antioxidants & Redox Signaling·Delira Robbins, Yunfeng Zhao
Feb 6, 2008·Biochimica Et Biophysica Acta·Chandan K Sen, Sashwati Roy
Aug 14, 2003·Fundamental & Clinical Pharmacology·Francis V DeFeudisKaty Drieu
Jan 30, 2009·Journal of Cellular and Molecular Medicine·Anja KoltermannStefan Zahler
Sep 2, 2006·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Jeysen Zivan YogaratnamSteve Griffin
Apr 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·D A CooleyW H Moore
Aug 15, 2013·Biomaterials·Megan S LordJohn M Whitelock
Jun 30, 2016·Antioxidants & Redox Signaling·Marten Hornsveld, Tobias B Dansen
Oct 6, 2018·Environmental Health and Toxicology·Byeonghak MoonSeung Min Oh
Sep 16, 2010·Free Radical Biology & Medicine·Simone ReuterBharat B Aggarwal

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M MonteE Sacerdote de Lustig
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