PMID: 6167708Jul 1, 1981Paper

Inhibition of lymphocyte transformation by mepacrine and chloroquine

The Journal of Pharmacy and Pharmacology
D G Trist, M Weatherall

Abstract

Mepacrine inhibited uptake and the incorporation of leucine, thymidine and uridine into acid-insoluble material in human lymphocytes stimulated by phytohaemagglutinin (PHA) in vitro. The IC50 for each uptake was of the order of 2 microM. Mepacrine was inhibitory if applied at any time up to 48 h after PHA. The inhibition differed from that produced by colchicine and prostaglandin E1. The dose-response curve was steep, nearly all incorporation being inhibited by 2 x IC50. Chloroquine also had a steep dose-response curve, was about one-fifth as potent as mepacrine and was maximally effective in the first 6 h after PHA.

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Citations

Apr 1, 1984·Annals of the Rheumatic Diseases·C J Jones, M I Jayson
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·I C Bygbjerg, H Flachs
May 1, 1983·Journal of the American Academy of Dermatology·D M Stoll
Apr 9, 2008·Applied Ergonomics·Alvaro D Taveira
Jun 8, 2006·Applied Ergonomics·Pascale Carayon
Dec 1, 1990·Baillière's Clinical Rheumatology·S TettR Day
Jan 1, 1989·International Journal of Health Services : Planning, Administration, Evaluation·R Karasek
Apr 15, 2014·Review of Human Factors and Ergonomics·Pascale CarayonTosha B Wetterneck
Feb 1, 1982·The Journal of Pharmacy and Pharmacology·D G Trist, M Weatherall

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