PMID: 6159511Oct 25, 1980Paper

Inhibition of lymphoma hybrids by human interferon

Lancet
K SikoraT Merigan

Abstract

A set of stable mouse-human hybrids was constructed from the neoplastic lymphocytes from a patient with nodular lymphoma and from another with chronic lymphocytic leukaemia. Both patients had shown a clinical response to human leucocyte interferon. The same interferon preparation inhibited the growth rate of 14 out of 17 established hybrid cell lines. This system provides evidence of a direct growth inhibitory effect of interferon on neoplastic B lymphocytes. Such a system could be used to predict the sensitivity of a patient's tumour before therapy.

References

Nov 1, 1976·CRC Critical Reviews in Biochemistry·H M Johnson, S Baron
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R Levy, J Dilley
Apr 15, 1977·International Journal of Cancer. Journal International Du Cancer·H Strander, S Einhorn
Sep 18, 1977·Blut·H Strander
Jul 15, 1982·Klinische Wochenschrift·H KirchnerE Storch

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