Inhibition of Lysyl Oxidase and Lysyl Oxidase-Like Enzymes Has Tumour-Promoting and Tumour-Suppressing Roles in Experimental Prostate Cancer

Scientific Reports
Maria NilssonSofia Halin Bergström

Abstract

Lysyl oxidase (LOX) and LOX-like (LOXL) enzymes are key players in extracellular matrix deposition and maturation. LOX promote tumour progression and metastasis, but it may also have tumour-inhibitory effects. Here we show that orthotopic implantation of rat prostate AT-1 tumour cells increased LOX and LOXLs mRNA expressions in the tumour and in the surrounding non-malignant prostate tissue. Inhibition of LOX enzymes, using Beta-aminopropionitrile (BAPN), initiated before implantation of AT-1 cells, reduced tumour growth. Conversely, treatment that was started after the tumours were established resulted in unaffected or increased tumour growth. Moreover, treatment with BAPN did not suppress the formation of spontaneous lymph node metastases, or lung tumour burden, when tumour cells were injected intravenously. A temporal decrease in collagen fibre content, which is a target for LOX, was observed in tumours and in the tumour-adjacent prostate tissue. This may explain why early BAPN treatment is more effective in inhibiting tumour growth compared to treatment initiated later. Our data suggest that the enzymatic function of the LOX family is context-dependent, with both tumour-suppressing and tumour-promoting properties in prostat...Continue Reading

References

Aug 16, 1991·Science·K KenyonR M Friedman
Feb 11, 2003·Journal of Cellular Biochemistry·Herbert M Kagan, Wande Li
Aug 30, 2003·Oncogene·Nicholas C DenkoAmato J Giaccia
Oct 11, 2003·The Journal of Biological Chemistry·Moon Suk KimYoungho Kim
Jan 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jacques LapointeJonathan R Pollack
Jul 28, 2004·The Journal of Biological Chemistry·Amitha H PalamakumburaPhilip C Trackman
Mar 29, 2005·American Journal of Surgery·Amy R WoznickCharles J Shanley
Aug 13, 2005·The EMBO Journal·Héctor PeinadoFrancisco Portillo
Apr 28, 2006·Nature·Janine T ErlerAmato J Giaccia
Nov 1, 2006·Matrix Biology : Journal of the International Society for Matrix Biology·Matthias K Jansen, Katalin Csiszar
May 2, 2007·Journal of Cellular Biochemistry·Stacey L PayneDawn A Kirschmann
Nov 26, 2009·Cell·Kandice R LeventalValerie M Weaver
May 5, 2010·The Journal of Biological Chemistry·Hector M RodriguezVictoria Smith
Aug 7, 2010·Neoplasia : an International Journal for Oncology Research·Samata M KakkadKristine Glunde
Jan 15, 2011·Cancer Research·Holly E BarkerJanine T Erler
Mar 2, 2011·The Prostate·Ashley E RossEdward M Schaeffer
Sep 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Carmen Chak-Lui WongGregg L Semenza
Sep 29, 2011·Investigative Ophthalmology & Visual Science·Matthias ZenkelUrsula Schlötzer-Schrehardt
Jul 20, 2012·Nature Reviews. Cancer·Holly E BarkerJanine T Erler
Aug 13, 2013·Breast Cancer Research and Treatment·Sung Gwe AhnJeffrey E Green
Sep 7, 2013·Molecular Cancer Research : MCR·Holly E BarkerJanine T Erler
Jul 23, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carmen Chak-Lui WongIrene Oi-Lin Ng
Sep 14, 2014·Journal of Cancer Research and Clinical Oncology·Rong-Kun LiZhi-Gang Zhang

❮ Previous
Next ❯

Citations

Mar 27, 2018·Carcinogenesis·Ana de la CuevaKathrin H Kirsch
Feb 23, 2018·The Journal of Cell Biology·Florence Broders-BondonEmmanuel Farge
May 19, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yoon Jin ChaJa Seung Koo
Oct 28, 2019·Cancer Immunology, Immunotherapy : CII·Paolo Tenti, Luca Vannucci
May 30, 2017·Stem Cells International·Aline Lopes RibeiroOswaldo Keith Okamoto
May 21, 2019·Frontiers in Cell and Developmental Biology·Tianyi LiuYuhang Zhang
Oct 23, 2019·Frontiers in Cell and Developmental Biology·Bridget MartinezDavid Mascareñas
Dec 21, 2017·International Journal of Molecular Sciences·Woo Young SunJa Seung Koo
Jul 28, 2018·Nature Cell Biology·Toni Celià-Terrassa, Yibin Kang
Dec 30, 2020·International Journal of Molecular Sciences·Hung-Yu LinPei-Yi Chu
Nov 17, 2020·Frontiers in Immunology·Antonella SistiguRuggero De Maria
Feb 20, 2020·Experimental Eye Research·Alison G GreeneDeborah M Wallace
Jun 28, 2021·Drug Delivery and Translational Research·Samira Aghlara-FotovatOmid Veiseh
Aug 15, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·May T MaungTeresita Padilla-Benavides

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay

Software Mentioned

Adobe Photoshop
Pannoramic Viewer
Photoshop
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.