PMID: 9172018Dec 1, 1996Paper

Inhibition of macrophage nitric oxide production by tetrahydrocannabinol in vivo and in vitro

International Journal of Immunopharmacology
R G CoffeyS Pross

Abstract

delta 9-Tetrahydrocannabinol (THC, 10 micrograms) was administered intraperitoneally to thioglycollate-treated mice. After 18 h, peritoneal macrophages were harvested and nitric oxide (NO.) production was induced by lipopolysaccharide (LPS, 1 microgram/ml) and interferon-gamma (IFN-gamma, 0.1-10 U/ml). Macrophages from THC-treated mice produced about half as much NO. as controls. THC (1 microgram/ml) added in vitro caused further inhibition. Greater inhibition was observed at the lower (0.1-0.3 U/ml) IFN-gamma concentrations. The results suggest that the use of THC can reduce NO. production and thereby affect host defense mechanisms, inflammation and autoimmune responses.

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Citations

Jan 27, 2004·Journal of Neuroimmunology·Michael D RothGayle C Baldwin
Dec 31, 2002·Chemistry and Physics of Lipids·Michael D RothDonald P Tashkin
Jan 13, 2006·Annual Review of Pharmacology and Toxicology·Ken Mackie
Feb 25, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Julie C WilliamsMaureen M Goodenow
Aug 10, 2000·European Journal of Biochemistry·M SalzetV Di Marzo
Feb 6, 2004·British Journal of Pharmacology·Lisa Walter, Nephi Stella
Apr 16, 2016·Neuropharmacology·John-Mark K Fitzpatrick, Eric J Downer
Feb 26, 2015·Pharmacological Reports : PR·Magdalena Bujalska-ZadrożnyKarolina Pawlik
Oct 4, 2016·Frontiers in Pharmacology·Caroline TurcotteNicolas Flamand
Jul 5, 2017·Epilepsia·Jacqueline A FrenchMarc A Dichter
May 3, 2011·Polish Journal of Veterinary Sciences·K Dudek, D Bednarek
Jan 11, 2021·Clinical Pharmacology and Therapeutics·Lael M YonkerBryan P Hurley
Jul 7, 2009·Pharmacology & Therapeutics·Andrea Huwiler, Josef Pfeilschifter
Oct 9, 2021·Chemical Research in Toxicology·Jiries Meehan-Atrash, Irfan Rahman

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