PMID: 4352791Jun 1, 1973Paper

Inhibition of malignant cell invasion in vitro by a proteinase inhibitor

British Journal of Cancer
A L LatnerK Pradhan

Abstract

The inhibitory effect of the protease inhibitor aprotinin (Trasylol) on the invasion of mouse kidney explants by polyoma virus transformed BHK21 cells was investigated using a mixed cell/organ culture technique. The extent of invasion was monitored by following the changes in LDH isoenzyme pattern in the explants and by histological assessment. The kidney explants containing aprotinin were found to maintain a normal kidney LDH pattern and to suffer considerably less invasion than the explants not containing the drug. These results support the idea that proteolytic enzymes are associated with invasion and that inhibitors of protease activity could possibly be useful in the management of clinical cancer.

Citations

Jun 1, 1989·Diseases of the Colon and Rectum·W G SheridanH L Young
May 1, 1974·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·C A RubioN Einhorn
Aug 1, 1993·Cell Biophysics·R M LafrenieF W Orr
Feb 6, 1979·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·G Horpacsy, K Schröder
Jan 1, 1983·Cancer Metastasis Reviews·M M Mareel
May 1, 1985·The British Journal of Surgery·P DurdeyN S Williams
Mar 1, 1988·Clinical & Experimental Metastasis·E PrangeH Pralle
Sep 1, 1990·Digestive Diseases and Sciences·F G VillamilJ M Oyhamburu
Sep 1, 1977·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N Back, P P Leblanc
Oct 1, 1979·The Journal of Investigative Dermatology·R M FineD Rudman

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