PMID: 7542394Apr 1, 1995Paper

Inhibition of MAO-B protects against MDMA-induced neurotoxicity in the striatum

Psychopharmacology
J E Sprague, D E Nichols

Abstract

The effects of the MAO-B inhibitors, L-deprenyl and MDL-72974 on MDMA-induced serotonergic neurotoxicity in rats were examined. MDMA alone produced a significant decrease in the number of 5-HT uptake sites, measured as a decrease in the Bmax for binding of [3H]paroxetine, and in 5-HT and 5-HIAA levels in the striatum. L-Deprenyl and MDL-72974 attenuated this MDMA-induced decrease in serotonergic markers. The data suggest a key role for MAO-B in the expression of the neurotoxicity produced by MDMA in the striatum.

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Citations

Apr 24, 2007·Neurotoxicity Research·Jean Lud CadetJohnalyn Lyles
Aug 19, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Bryan K Yamamoto, Jamie Raudensky
Apr 18, 2009·Molecular Neurobiology·João Paulo CapelaFélix Carvalho
Mar 12, 1999·Neuroscience and Biobehavioral Reviews·K M HegadorenM Bourin
May 10, 2003·Brain Research. Brain Research Reviews·Johnalyn Lyles, Jean Lud Cadet
Jun 14, 2000·Progress in Neurobiology·I J MitchellM R Griffiths
Jul 2, 2008·Parkinsonism & Related Disorders·P FoleyP Riederer
Aug 5, 1999·British Journal of Pharmacology·V PérezM Unzeta
Oct 27, 2015·Neurotoxicity Research·Krystyna GołembiowskaAnna Górska
Mar 7, 2015·Archives of Toxicology·Daniel José BarbosaFélix Carvalho
Dec 19, 2017·Psychopharmacology·Elizabeth G PittsLeonard L Howell

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