Inhibition of mast cell infiltration in an LL-37-induced rosacea mouse model using topical brimonidine tartrate 0.33% gel

Experimental Dermatology
Miri KimHyun Jeong Park

Abstract

Brimonidine is a highly selective α2-adrenergic receptor agonist approved by the FDA for the treatment of rosacea. Rosacea is a major clinical disease with vasodilatation and rash on the centre of the face, and that brimonidine as a vasoconstrictor can act as a remedy for rosacea. However, there is no study of how brimonidine has an effect on rosacea-related immune cells or mechanisms in the skin to improve rosacea. In this study, we observed that clinical features of rosacea induced by LL-37 in Balb/c mice were improved after the application of brimonidine gel, and we also showed a marked decrease in the number of inflammatory cells, especially mast cells (MCs) histologically. Furthermore, we confirmed that mRNA levels of MC enzymes increased by LL-37 were reduced by brimonidine gel. To our knowledge, we first found that brimonidine has a mechanism of treating rosacea by reducing the number and mRNA levels of MC-specific enzymes, an important immune cell in the pathogenesis of rosacea.

References

Dec 24, 2004·The Journal of Biological Chemistry·Elena TchougounovaGunnar Pejler
May 15, 2007·Immunological Reviews·George H Caughey
May 23, 2014·The Journal of Investigative Dermatology·Yumiko MutoAnna Di Nardo
Dec 20, 2014·The British Journal of Dermatology·R A DorschnerR L Gallo
Apr 22, 2015·Journal of the American Academy of Dermatology·Aimee M TwoTissa R Hata

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Citations

Feb 13, 2020·Frontiers in Medicine·Lian WangXian Jiang
Feb 19, 2021·Expert Opinion on Emerging Drugs·Federica Dall'OglioGiuseppe Micali
Apr 20, 2021·Journal of Cosmetic Dermatology·Hanlin ZhangQiuning Sun
Sep 4, 2021·Dermatology and Therapy·Mark C Marchitto, Anna L Chien

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