PMID: 9192515Jul 1, 1997Paper

Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (clodronate)

Calcified Tissue International
Olli TeronenT Sorsa

Abstract

Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an extended and hitherto undescribed properties for clodronate/biphosphonates in prevention and treatment of tissue degradation in both bone and soft tissue destructive diseases.

Citations

Feb 24, 2001·Dental Materials : Official Publication of the Academy of Dental Materials·A P de SouzaS R Line
Oct 12, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·Y T KonttinenC López-Otín
Apr 6, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A Lochter, M J Bissell
Jul 23, 1999·Annals of the New York Academy of Sciences·O TeronenT Sorsa
Jan 5, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S DerenneR Bataille
Jun 11, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Martine M L DeckersClemens W G M Löwik
Apr 2, 2002·Journal of Periodontology·Veruska B M AlencarRonaldo A Ribeiro
Feb 24, 2001·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·L C FigueiredoS L Salvador
Dec 18, 2007·Biochimica Et Biophysica Acta·Thomas J Wilson, Rakesh K Singh
May 7, 2005·International Endodontic Journal·R LeonardiC Loreto
Jun 28, 2005·Dental Clinics of North America·Mario TabaWilliam V Giannobile
Jan 28, 2003·Cancer·Jonathan R Green
Mar 26, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·B Murat CınarReha N Tandogan
Aug 29, 2018·Equine Veterinary Journal·A MitchellA E Watts
Mar 11, 2003·Prostate Cancer and Prostatic Diseases·G M OadesK W Colston
Jul 12, 2020·International Journal of Environmental Research and Public Health·Vittorio ChecchiAnnalisa Mazzoni
Dec 7, 2013·Molecular Cancer Therapeutics·Marie R WebsterCaren L Freel Meyers
Nov 24, 2019·Archives of Oral Biology·Nubia Rosa PriettoFábio Renato Manzolli Leite
May 4, 1999·Clinical and Diagnostic Laboratory Immunology·R GendronD Mayrand

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