Inhibition of melanogenesis by sodium 2-mercaptoethanesulfonate

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Jeong-Hwan KimBeom Joon Kim

Abstract

Sodium 2-mercaptoethanesulfonate (mesna) is a protective agent that is widely used in medicine because of its antioxidant effects. Recently, reactive oxygen species (ROS) were shown to increase pigmentation. Thus, ROS scavengers and inhibitors of ROS production may suppress melanogenesis. Forkhead box-O3a (FoxO3a) is an antimelanogenic factor that mediates ROS-induced skin pigmentation. In this study, we aimed to investigate the whitening effect of mesna and the signaling mechanism mediating this effect. Human melanoma (MNT-1) cells were used in this study. mRNA and protein expression were measured by real-time quantitative PCR and Western blotting analysis to track changes in FoxO3a-related signals induced by mesna. An immunofluorescence assay was performed to determine the nuclear translocation of FoxO3a. When MNT-1 melanoma cells were treated with mesna, melanin production and secretion decreased. These effects were accompanied by increases in FoxO3a activation and nuclear translocation, resulting in downregulation of four master genes of melanogenesis: MITF, TYR, TRP1, and TRP2. We found that mesna, an antioxidant and radical scavenger, suppresses melanin production and may therefore be a useful agent for the clinical treat...Continue Reading

References

Oct 1, 1993·The Biochemical Journal·J R RosF García-Cánovas
Jan 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R SkinnerA W Craft
Jul 10, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·S UraY Gotoh
May 2, 2003·Bioscience, Biotechnology, and Biochemistry·Yukimitsu MasamotoKyoya Takahata
May 29, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·Chang-Hun HuhKyung-Chan Park
May 22, 2008·International Journal of Cosmetic Science·C D Villarama, H I Maibach
Apr 20, 2010·Journal of Dermatological Science·Hitoshi Masaki
Sep 17, 2011·Journal of the American Academy of Dermatology·Vaneeta M Sheth, Amit G Pandya
Oct 12, 2012·Acta neurochirurgica·Erdal Resit YilmazZeki Sekerci
Jul 25, 2013·American Journal of Clinical Dermatology·Shelly Rivas, Amit G Pandya
Oct 19, 2013·Biochemical and Biophysical Research Communications·Teng YuYong-li Guo
Nov 29, 2013·The Journal of Investigative Dermatology·Juewon KimTae R Lee

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
protein assay
nuclear translocation

Software Mentioned

DP controller

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved