PMID: 6400921Oct 1, 1984Paper

Inhibition of metabolic cooperation in Chinese hamster V79 cells by various organic solvents and simple compounds

Cell Biology and Toxicology
T H ChenJ E Trosko

Abstract

Gap-junctional intercellular communication is a biological process implicated in the regulation of cell proliferation and differentiation. Metabolic cooperation between 6-thioguanine-sensitive and resistant Chinese hamster cells, in vitro, has been used as a means to detect chemicals which can inhibit this form of intercellular communication. To further characterize this in vitro system as a potential screening assay for potential teratogens, tumor promoters and reproductive toxicants, a series of common solvents as well as other chemicals representing eight different functional groups, i.e., alcohols with straight or side chains, glycols, ketones, esters, ethers, phenols, aldehydes, amines and amino compounds and oxygen-heterocyclic compounds, were tested for their ability to inhibit colony-formation and to inhibit metabolic cooperation. A wide range of effects were observed which suggested a structure/activity relationship between a chemical's ability to inhibit gap junction-mediated intercellular communication and the cytotoxicity of a chemical. Possible mechanisms affecting the modulation of gap junctional communication by these chemicals are discussed.

References

May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S J CollinsR C Gallo
Nov 9, 1979·Science·F A SchanneJ L Farber
Nov 28, 1979·Biochemical and Biophysical Research Communications·A W Murray, D J Fitzgerald
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Jan 1, 1974·CRC Critical Reviews in Toxicology·R K Boutwell
Jan 1, 1982·Teratogenesis, Carcinogenesis, and Mutagenesis·J E TroskoM Netzloff
Jan 1, 1984·Teratogenesis, Carcinogenesis, and Mutagenesis·F Welsch, D B Stedman
Oct 1, 1981·Physiological Reviews·W R Loewenstein
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D C SprayM V Bennett
Apr 29, 1982·Biochimica Et Biophysica Acta·M L Hooper
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J E NiedelG R Vandenbark
Jan 1, 1983·Cancer Investigation·J E TroskoA Medcalf
Oct 1, 1984·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·C RubinsteinC C Chang
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T G Hartman, J D Rosen
Nov 20, 1981·Science·K K SulikM A Webb
Mar 1, 1982·Cell Biology International Reports·D J Fitzgerald, A W Murray
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T EnomotoH Yamasaki
Apr 17, 1981·Science·F A SchanneE Rubin
Dec 1, 1980·The Journal of Cell Biology·C Peracchia, L L Peracchia
Nov 1, 1981·Wilhelm Roux's Archives of Developmental Biology·Yoshiki Shiba

❮ Previous
Next ❯

Citations

Apr 1, 1988·Cancer Metastasis Reviews·H Yamasaki
Jan 1, 1989·Cell Biology and Toxicology·L Wärngård, S Flodström
Oct 29, 2003·Toxicology Letters·I F DelgadoF J R Paumgartten
Jun 1, 1994·Risk Analysis : an Official Publication of the Society for Risk Analysis·J E TroskoB V Madhukar
Jan 1, 1985·Critical Reviews in Toxicology·R Loch-Caruso, J E Trosko
Oct 1, 1991·Toxicology and Applied Pharmacology·S C McKarns, D J Doolittle
Jun 4, 2002·International Journal of Toxicology·Wilbur Johnson, UNKNOWN Cosmetic Ingredient Review Expert panel
Apr 29, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariya ChigrinovaPaul Pezacki
Oct 1, 1987·Diabetes/metabolism Reviews·J Barbosa, F H Bach
Jan 1, 1985·Teratogenesis, Carcinogenesis, and Mutagenesis·C M JoneC C Chang
Feb 1, 1986·Applied Biochemistry and Biotechnology·R J Lindhardt
May 1, 1988·Mutation Research·E M Faustman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.