PMID: 25556474Jan 6, 2015Paper

Inhibition of metastasis and invasion of ovarian cancer cells by crude polysaccharides from rosa roxburghii tratt in vitro

Asian Pacific Journal of Cancer Prevention : APJCP
Yang ChenWei-Ling Li


Rosa Roxburghii Tratt is a promising wild fruit crop in Southwest China. Its extracts have been used as traditional Chinese medicine, which benefit immune responses and cure various health disorders. However, whether Rosa Roxburghii Tratt polysaccharides could inhibit metastasis and invasion of ovarian cancer cells remains unknown. Effects of crude polysaccharides from Rosa Roxburghii Tratt on the viability of ovarian cancer A2780 cells were detected by MTT assay. Ovarian carcinoma cell migration and invasion after exposure to Rosa Roxburghii Tratt polysaccharides were quantified by wound healing and Transwell assays, respectively. Western blotting was applied to assess protein levels of MMP-9. The results indicated that Rosa Roxburghii Tratt polysaccharides significantly reduced wound closure rate of A2780 cells, inhibited their migration and invasion, and suppressed the expression of MMP-9. Our findings indicated that Rosa Roxburghii Tratt polysaccharides have potential for develop as anti-metastatic cancer drug preparations for ovarian cancer patients.


Jun 1, 1997·Mechanisms of Ageing and Development·Y X MaL He
Apr 23, 2003·European Urology·Motohiro KanazawaTsuneharu Miki
Nov 10, 2005·The Journal of Pathology·Marisa Parmo-CabañasJoaquin Teixidó
Jun 26, 2007·Cells, Tissues, Organs·Melody Stallings-Mann, Derek Radisky
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Mar 18, 2008·Critical Reviews in Oncology/hematology·Phuong DinhAhmad Awada
May 5, 2010·Journal of Agricultural and Food Chemistry·Xingbin YangYan Zhao
Sep 24, 2011·Nature Reviews. Cancer·Sebastian VaughanFrances R Balkwill
Aug 21, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Wei LiuHua Zhang
Oct 27, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Zhao ShanZhou Ting
Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Li-Na LiJun Yan
Oct 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Zhao-Ling SunP Han
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Aug 16, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Sevim Kalsen ArikanSumeyra Tatar


Sep 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Meng-Hua LiuJing-Yu He
Sep 19, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jihong ZhanYinxue Guo
Apr 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta OlechRenata Nowak
Jun 8, 2017·International Journal of Molecular Sciences·Inés MármolMaría Jesús Rodríguez-Yoldi
May 22, 2017·International Journal of Biological Macromolecules·Yandong ZhangChunshui Liu
Mar 22, 2021·Frontiers in Cell and Developmental Biology·Jinlong LiuPeng Qu

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.