PMID: 25556474Jan 6, 2015Paper

Inhibition of metastasis and invasion of ovarian cancer cells by crude polysaccharides from rosa roxburghii tratt in vitro

Asian Pacific Journal of Cancer Prevention : APJCP
Yang ChenWei-Ling Li

Abstract

Rosa Roxburghii Tratt is a promising wild fruit crop in Southwest China. Its extracts have been used as traditional Chinese medicine, which benefit immune responses and cure various health disorders. However, whether Rosa Roxburghii Tratt polysaccharides could inhibit metastasis and invasion of ovarian cancer cells remains unknown. Effects of crude polysaccharides from Rosa Roxburghii Tratt on the viability of ovarian cancer A2780 cells were detected by MTT assay. Ovarian carcinoma cell migration and invasion after exposure to Rosa Roxburghii Tratt polysaccharides were quantified by wound healing and Transwell assays, respectively. Western blotting was applied to assess protein levels of MMP-9. The results indicated that Rosa Roxburghii Tratt polysaccharides significantly reduced wound closure rate of A2780 cells, inhibited their migration and invasion, and suppressed the expression of MMP-9. Our findings indicated that Rosa Roxburghii Tratt polysaccharides have potential for develop as anti-metastatic cancer drug preparations for ovarian cancer patients.

References

Jun 1, 1997·Mechanisms of Ageing and Development·Y X MaL He
Apr 23, 2003·European Urology·Motohiro KanazawaTsuneharu Miki
Nov 10, 2005·The Journal of Pathology·Marisa Parmo-CabañasJoaquin Teixidó
Jun 26, 2007·Cells, Tissues, Organs·Melody Stallings-Mann, Derek Radisky
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Mar 18, 2008·Critical Reviews in Oncology/hematology·Phuong DinhAhmad Awada
May 5, 2010·Journal of Agricultural and Food Chemistry·Xingbin YangYan Zhao
Sep 24, 2011·Nature Reviews. Cancer·Sebastian VaughanFrances R Balkwill
Aug 21, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Wei LiuHua Zhang
Oct 27, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Zhao ShanZhou Ting
Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Li-Na LiJun Yan
Oct 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Zhao-Ling SunP Han
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Aug 16, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Sevim Kalsen ArikanSumeyra Tatar

Citations

Sep 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Meng-Hua LiuJing-Yu He
Sep 19, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jihong ZhanYinxue Guo
Apr 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta OlechRenata Nowak
Jun 8, 2017·International Journal of Molecular Sciences·Inés MármolMaría Jesús Rodríguez-Yoldi
May 22, 2017·International Journal of Biological Macromolecules·Yandong ZhangChunshui Liu
Mar 22, 2021·Frontiers in Cell and Developmental Biology·Jinlong LiuPeng Qu

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