Inhibition of Methane Oxidation by Methylococcus capsulatus with Hydrochlorofluorocarbons and Fluorinated Methanes.

Applied and Environmental Microbiology
L J MathesonR S Oremland

Abstract

The inhibition of methane oxidation by cell suspensions of Methylococcus capsulatus (Bath) exposed to hydrochlorofluorocarbon 21 (HCFC-21; difluorochloromethane [CHF(inf2)Cl]), HCFC-22 (fluorodichloromethane [CHFCl(inf2)]), and various fluorinated methanes was investigated. HCFC-21 inhibited methane oxidation to a greater extent than HCFC-22, for both the particulate and soluble methane monooxygenases. Among the fluorinated methanes, both methyl fluoride (CH(inf3)F) and difluoromethane (CH(inf2)F(inf2)) were inhibitory while fluoroform (CHF(inf3)) and carbon tetrafluoride (CF(inf4)) were not. The inhibition of methane oxidation by HCFC-21 and HCFC-22 was irreversible, while that by methyl fluoride was reversible. The HCFCs also proved inhibitory to methanol dehydrogenase, which suggests that they disrupt other aspects of C(inf1) catabolism in addition to methane monooxygenase activity.

References

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Citations

Jan 15, 1999·Critical Reviews in Microbiology·J P SullivanH A Chase
Oct 31, 1998·Applied and Environmental Microbiology·L G MillerR S Oremland
Feb 18, 2004·Journal of Environmental Quality·Charlotte Scheutz, Peter Kjeldsen
Nov 5, 1999·Applied and Environmental Microbiology·J K Schaefer, R S Oremland
Nov 27, 2001·Waste Management & Research : the Journal of the International Solid Wastes and Public Cleansing Association, ISWA·G Börjesson

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