PMID: 8971728Dec 1, 1996Paper

Inhibition of minK protein induced K+ channels in Xenopus oocytes by estrogens

Naunyn-Schmiedeberg's Archives of Pharmacology
S WaldeggerA E Busch

Abstract

Previously it was shown that minK protein expression in uterus is regulated by estrogen. In the present study, we were interested in putative direct effects of estrogen on minK protein induced K+ currents (IminK) in Xenopus oocytes. Superfusion with 17-beta-estradiol (1 microM) resulted in an inhibition of minK-induced currents, but had no appreciable effects on the delayed rectifier and inward rectifier K+ channels Kv1.1 and Kir2.1, respectively. The inhibition of IminK by 17-beta-estradiol was concentration-dependent, with an IC50 of approximately 0.5 microM. In the presence of 17-beta-estradiol, the conductance-voltage relationship was shifted to more depolarized potentials. IminK inhibition occurred also in the presence of the estrogen-receptor antagonist tamoxifen, suggesting that a mechanism independent of estrogen receptors is involved. The synthetic estrogen diethylstilbestrol (DES) also inhibited IminK but with a lower affinity (IC50 of 4.5 microM), while cortisol and progesterone had only weak effects on IminK. In summary, the results indicate that estrogens directly inhibit IminK.

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Citations

Aug 10, 1999·European Journal of Pharmacology·K OkabeH Soeda
Aug 14, 1999·Progress in Biophysics and Molecular Biology·Y Shimoni
Jan 1, 1997·Trends in Pharmacological Sciences·A E Busch, H Suessbrich
Aug 17, 2001·Hearing Research·J H Lee, D C Marcus
Oct 6, 1997·British Journal of Pharmacology·A E BuschW Stühmer
Mar 27, 2001·British Journal of Pharmacology·M L DoddsG J Kargacin
May 5, 2001·Expert Opinion on Pharmacotherapy·J Nemec, W K Shen
Apr 7, 2004·Fundamental & Clinical Pharmacology·Najah Abi-GergesJean-Pierre Valentin
May 30, 2001·Biochemical Pharmacology·Y M ShubaR L Woosley
May 18, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Katrin Sak, Hele Everaus
Feb 17, 2006·European Journal of Pharmacology·Clemens Möller, Rainer Netzer
Jul 2, 2005·Journal of Cellular Physiology·Lars KunzArtur Mayerhofer
Aug 2, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M D Drici, N Clément
Sep 21, 2006·American Journal of Physiology. Renal Physiology·Sandra M MalakauskasThu H Le
Aug 3, 2007·American Journal of Physiology. Cell Physiology·Florian LangPhiline Wangemann
Sep 9, 2000·Journal of Neurophysiology·Z Li, M Hay
Apr 19, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jianying HeChristopher A Ward

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