Inhibition of mitochondria ATP synthase suppresses prostate cancer growth through reduced insulin-like growth factor-1 secretion by prostate stromal cells.

International Journal of Cancer. Journal International Du Cancer
Tomokazu OhishiManabu Kawada

Abstract

Modulation of prostate stromal cells (PrSCs) within tumor tissues is gaining attention for the treatment of solid tumors. Using our original in vitro coculture system, we previously reported that leucinostatin (LCS)-A, a peptide mycotoxin, inhibited prostate cancer DU-145 cell growth through reduction of insulin-like growth factor 1 (IGF-I) expression in PrSCs. To further obtain additional bioactive compounds from LCS-A, we designed and synthesized a series of LCS-A derivatives as compounds that target PrSCs. Among the synthesized LCS-A derivatives, LCS-7 reduced IGF-I expression in PrSCs with lower toxicity to PrSCs and mice than LCS-A. As LCS-A has been suggested to interact with mitochondrial adenosine triphosphate (ATP) synthase, a docking study was performed to elucidate the mechanism of reduced IGF-I expression in the PrSCs. As expected, LCS-A and LCS-7 directly interacted with mitochondrial ATP synthase, and like LCS-A and LCS-7, other mitochondrial ATP synthase inhibitors also reduced the expression of IGF-I by PrSCs. Furthermore, LCS-A and LCS-7 significantly decreased the growth of mouse xenograft tumors. Based on these data, we propose that the mitochondrial ATP synthases-IGF-I axis of PrSCs plays a critical role on ...Continue Reading

References

Jan 1, 1978·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A C FraschA O Stoppani
Oct 1, 1981·Journal of General Microbiology·M D Unitt, D Lloyd
Jan 1, 1996·International Journal of Urology : Official Journal of the Japanese Urological Association·G KimuraY Fujita-Yamaguchi
Jun 24, 1998·Journal of the National Cancer Institute·P Cohen
Jun 17, 2000·Endocrine Reviews·H M KhandwalaK E Friend
May 11, 2002·Science·Bryony S Wiseman, Zena Werb
Nov 22, 2002·Oncogene·Liarisa A ShchepinaVladimir P Skulachev
Feb 26, 2003·Cell·Donald D Newmeyer, Shelagh Ferguson-Miller
Mar 25, 1963·Biochemical and Biophysical Research Communications·E RACKER
Mar 31, 2006·Nature Reviews. Cancer·Raghu Kalluri, Michael Zeisberg
Mar 14, 2007·Urologic Oncology·Charles J RyanIra D Goldfine
Oct 2, 2009·International Journal of Cancer. Journal International Du Cancer·Manabu KawadaDaishiro Ikeda
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Katharina NimptschEdward Giovannucci
Oct 26, 2010·Nature Chemical Biology·Denys PogoryelovThomas Meier
Aug 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jindrich SymerskyDavid M Mueller
Apr 2, 2013·The Journal of Clinical Investigation·Douglas C Wallace
Jul 31, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Meijuan WuLuyong Zhang
Mar 20, 2014·British Journal of Pharmacology·Fabrice IvanesMichelangelo Campanella
Apr 23, 2014·Molecular and Cellular Biology·Tomokazu OhishiHiroyuki Seimiya
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Aug 2, 2015·Cancer Letters·Isabel HeideggerHelmut Klocker
Oct 26, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dongge CaiXiaoling Wu
Jun 13, 2018·Nature Medicine·Jennifer R MolinaJoseph R Marszalek
Sep 8, 2018·Journal of Cellular Biochemistry·Uzma SaqibMirza S Baig
Sep 23, 2018·Journal of Cellular Biochemistry·Uzma Saqib, Mirza S Baig
Feb 2, 2019·Journal of Clinical Biochemistry and Nutrition·Shuya KasaiKen Itoh

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Citations

Aug 26, 2020·International Journal of Molecular Sciences·Tomokazu OhishiManabu Kawada
Oct 28, 2020·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Takumi WatanabeMasakatsu Shibasaki
Sep 18, 2020·European Journal of Medicinal Chemistry·Bhargav A PatelBrian S J Blagg
Apr 14, 2021·Future Medicinal Chemistry·William A Denny
Jun 25, 2021·The Journal of Antibiotics·Manabu KawadaTomokazu Ohishi
Aug 10, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wen-Jun ZhangZhengming Zhu

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