Inhibition of mitochondrial protein synthesis promotes autonomous regulation of mtDNA expression and generation of a new mitochondrial RNA species

FEBS Letters
S P SelwoodZ M Chrzanowska-Lightowlers

Abstract

Mammalian mitochondria are known to proliferate in response to several stimuli. Proliferation requires an increase in expression of genes encoding proteins involved in mitochondrial biogenesis, as well as in the replication and expression of mitochondrial DNA (mtDNA). In contrast, we report that inhibiting mitochondrial protein synthesis causes a modulation in mtDNA gene expression without the concomitant increase in proliferative markers. Further, inhibition results in the production of a previously unidentified light-strand mitochondrial RNA that spans the entire displacement loop, the function of which is currently unknown.

References

Jul 1, 1991·Trends in Genetics : TIG·G CesareniL Castagnoli
Jun 1, 1990·Genes & Development·M J Evans, R C Scarpulla
Mar 1, 1989·European Journal of Biochemistry·A MutveiB D Nelson
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D D Chang, D A Clayton
Aug 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·Y Aloni, G Attardi
Jun 16, 1997·FEBS Letters·G V BörnerS Pääbo
Apr 1, 1997·Journal of Bioenergetics and Biomembranes·R C Scarpulla
Apr 1, 1997·Journal of Bioenergetics and Biomembranes·R W TaylorD M Turnbull
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y XiaJ B McMillin
Nov 7, 1998·The Journal of Biological Chemistry·D Y Lee, D A Clayton
Dec 22, 1998·Molecular and Cellular Biology·J A EnríquezJ Montoya
Sep 24, 1999·Biological Chemistry·J A EnríquezJ Montoya

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Citations

Jun 23, 2010·Nucleic Acids Research·Christoph FreyerNils-Göran Larsson
May 18, 2004·Trends in Genetics : TIG·Dominique GagliardiZofia M A Chrzanowska-Lightowlers
Nov 9, 2006·Free Radical Research·Rudolf J WiesnerWolfram S Kunz
Nov 1, 2005·The Journal of Biological Chemistry·José I Piruat, José López-Barneo
Jul 28, 2019·Cell Cycle·Simone A BaechlerYves Pommier
Sep 22, 2021·Open Biology·Katja E MengerThomas J Nicholls
Mar 10, 2010·Biochimica Et Biophysica Acta·Richard J TemperleyZofia M Chrzanowska-Lightowlers

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