Inhibition of mitogen mediated lymphocyte blastogenesis by adenosine

Immunological Communications
I H FoxD Cane

Abstract

The effect of adenosine on the proliferative response of human peripheral circulating lymphocytes to stimulation by concanavalin A, phytohemagglutinin and pokeweed mitogen was evaluated. Increasing concentrations of adenosine substantially inhibited mitogen mediated lymphocyte blastogenesis. Erythro-9(2-hydroxyl-3-nonyl) adenine. HCl enhanced the inhibitory effect of adenosine. Inosine, the deamination product of adenosine, had an inhibitory effect which was less than that of adenosine. Inhibition by adenosine may be relevant to the normal regulation of immune function and may account in part for the pathophysiological relationship between severe combined immunodeficiency disease and adenosine deaminase deficiency.

References

Oct 22, 1969·Biochimica Et Biophysica Acta·T L SteckJ P Bader
Dec 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·P V HauschkaR W Rubin
Jul 1, 1974·Pediatric Research·R L LevineN Kretchmer
Apr 8, 1974·Biochemical and Biophysical Research Communications·M B Van der WeydenW N Kelley
Jul 4, 1972·Biochemistry·S B Mizel, L Wilson

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Citations

Jan 1, 1982·The International Journal of Biochemistry·G J PetersJ H Veerkamp
May 15, 1977·Life Sciences·M B Van der Weyden, W N Kelley
Jan 1, 1983·International Journal of Immunopharmacology·G Sandberg
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A TeddeP P Trotta
Oct 1, 1976·British Journal of Haematology·M B Van der Weyden, W N Kelley
Jul 1, 1979·The Journal of Clinical Investigation·N S Magnuson, L E Perryman
Oct 1, 1978·The Journal of Pediatrics·F C SchmalstiegR M Goldblum
Dec 9, 1976·The New England Journal of Medicine·S H PolmarR Hirschhorn
Nov 1, 1977·Biochemical Pharmacology·J F HendersonC A Lomax
Aug 1, 1977·Cellular Immunology·R Hirschhorn, E Sela
Sep 15, 1981·Cellular Immunology·E M SordilloP P Trotta
Apr 1, 1980·La Ricerca in Clinica E in Laboratorio·G MaroneL M Lichtenstein

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