PMID: 20650113Aug 1, 1995Paper

Inhibition of mitotic-specific histone phosphorylation by sodium arsenite

Toxicology in Vitro : an International Journal Published in Association with BIBRA
J M CoboL R Gurley

Abstract

Synchronized cultures of Chinese hamster cells (line CHO) were used to measure the effects of 10 mum sodium arsenite on histone phosphorylation. This treatment caused cell proliferation to be temporarily arrested, after which the cells spontaneously resumed cell proliferation in a radiomimetic manner. Immediately following treatment, it was found that sodium arsenite affected only mitotic-specific H1 and H3 phosphorylations. Neither interphase, nor mitotic, H2A and H4 phosphorylations were affected, nor was interphase H1 phosphorylation affected. The phosphorylation of H1 was inhibited only in mitosis, reducing H1 phosphorylation to 38.1% of control levels, which was the level of interphase H1 phosphorylation. The phosphorylation of both H3 variants was inhibited in mitosis, the less hydrophobic H3 to 19% and the more hydrophobic H3 to 24% of control levels. These results suggest that sodium arsenite may inhibit cell proliferation by interfering with the cyclin B/p34(cdc2) histone kinase activity which is thought to play a key role in regulating the cell cycle. It has been proposed that H1 and H3 phosphorylations play a role in restructuring interphase chromatin into metaphase chromosomes. Interference in this process by sodium...Continue Reading

References

Mar 1, 1978·European Journal of Biochemistry·L R GurleyR A Tobey
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R A TobeyH A Crissman
Jan 1, 1986·Journal of Toxicology and Environmental Health·L R GurleyR A Tobey
Jan 16, 1973·Biochemistry·L R GurleyR A Walters
Dec 10, 1973·Biochemical and Biophysical Research Communications·L R Gurley, R A Walters
Apr 27, 1971·Biochemistry·L R Gurley, R A Walters
Feb 15, 1983·Analytical Biochemistry·L R GurleyW D Spall
Jun 1, 1983·The Science of the Total Environment·L R GurleyS S Barham
Jan 1, 1980·Journal of Toxicology and Environmental Health·L R GurleyR A Tobey
Jun 18, 1993·Cell·C J Sherr

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Citations

May 18, 1999·The Journal of Biological Chemistry·C HuangZ Dong
Nov 1, 2021·The Science of the Total Environment·Arijit ChakrabortySubhamoy Bhowmick

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