Inhibition of M/Kv 7 Currents Contributes to Chloroquine-Induced Itch in Mice

Frontiers in Molecular Neuroscience
Dong ZhangZhanfeng Jia

Abstract

M/Kv7 potassium channels play a key role in regulation of neuronal excitability. Modulation of neuronal excitability of primary sensory neurons determines the itch sensation induced by a variety of itch-causing substances including chloroquine (CQ). In the present study, we demonstrate that suppression of M/Kv7 channel activity contributes to generation of itch in mice. CQ enhances excitability of the primary sensory neurons through inhibiting M/Kv7 potassium currents in a Ca2+ influx-dependent manner. Specific M/Kv7 channel opener retigabine (RTG) or tannic acid (TA) not only reverses the CQ-induced enhancement of neuronal excitability but also suppresses the CQ-induced itch behavior. Systemic application of RTG or TA also significantly inhibits the itch behavior induced by a variety of pruritogens. Taken together, our findings provide novel insight into the molecular basis of CQ-induced itch sensation in mammals that can be applied to the development of strategies to mitigate itch behavior.

References

Feb 7, 1998·Science·C BiervertO K Steinlein
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·H CruzblancaB Hille
Mar 17, 2001·Nature Reviews. Neuroscience·T J Jentsch
May 23, 2002·Science·Andrea M PeierArdem Patapoutian
Jun 18, 2003·The Journal of General Physiology·Nikita Gamper, Mark S Shapiro
Jul 22, 2006·The Journal of Investigative Dermatology·Makoto AsakawaTsuneaki Sakata
Jan 9, 2007·The Journal of Allergy and Clinical Immunology·Paul J DunfordRobin L Thurmond
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Won-Sik ShimUhtaek Oh
Apr 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert A CrozierMark H Pausch
Apr 4, 2008·The New England Journal of Medicine·Thomas Bieber
May 2, 2008·American Journal of Physiology. Cell Physiology·Boyi LiuHailin Zhang
Aug 30, 2008·The Journal of Investigative Dermatology·Takeshi YoshiokaAkinori Arimura
Sep 16, 2008·Pain·Steven G Shimada, Robert H LaMotte
Oct 31, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John E LinleyNikita Gamper
Mar 21, 2009·British Journal of Pharmacology·David A Brown, Gayle M Passmore
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kristofer K RauH Richard Koerber
Oct 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mariusz MuchaIan C Wood
Aug 17, 2011·The Journal of General Physiology·Xu-Feng ZhangDi Zhang
Nov 1, 2011·The Journal of Allergy and Clinical Immunology·F Estelle R Simons, Keith J Simons
Mar 13, 2012·American Journal of Human Genetics·Zhimiao LinYong Yang
Apr 6, 2012·The Journal of Investigative Dermatology·Erika Yamamoto-KasaiTakeshi Yoshioka
Apr 20, 2012·Acta Dermato-venereologica·Jessica M SpradleyEarl Carstens
Oct 19, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qin LiuXinzhong Dong
Mar 20, 2013·The Journal of Biological Chemistry·Jonathan Y-X L ThanXuming Zhang
Jan 31, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew B Young, Steven A Thomas
Apr 2, 2014·The Journal of Comparative Neurology·Chih H KingSteven S Scherer
Apr 24, 2014·Journal of Ethnopharmacology·Ben A ChindoAxel Becker
May 14, 2014·Annual Review of Biophysics·Liang Han, Xinzhong Dong
Jul 24, 2014·Epilepsia·Nicholas M AllenMary D King
Feb 6, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sonya M BierbowerMark S Shapiro

❮ Previous
Next ❯

Software Mentioned

Origin
Clampfit
SPSS

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

California State Journal of Medicine
D W Montgomery
The British and Foreign Medico-chirurgical Review
Journal of Pain and Symptom Management
E J Madden
© 2021 Meta ULC. All rights reserved