PMID: 6413976Oct 1, 1983Paper

Inhibition of muscle differentiation by trypanosoma cruzi

Proceedings of the National Academy of Sciences of the United States of America
K S RowinB Nadal-Ginard

Abstract

L6E9 rat myoblasts were infected in tissue culture with the myotropic Brazil strain of Trypanosoma cruzi. The effect of parasite infection on the ability of myoblasts to differentiate into myotubes was studied. Both morphological and biochemical differentiation were found to be profoundly affected by parasitic infection in a dose-related fashion. Evidence is presented to suggest that infected myoblasts can no longer differentiate. Differentiation, once underway, seemed unaffected by the parasitic infection; biochemical markers of differentiation remained intact.

References

Jun 1, 1978·Annals of the Rheumatic Diseases·W CossermelliM Shiroma
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·H HoltzerA Kaji
Jan 1, 1976·Developmental Biology·R O HynesC J Epstein
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G M WahlG R Stark
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J C AlwineG R Stark
Jul 1, 1975·Experimental Cell Research·D Delain, J P Wahrmann
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R M MedfordB Nadal-Ginard
Nov 1, 1964·Progress in Cardiovascular Diseases·M B ROSENBAUM

❮ Previous
Next ❯

Citations

Jan 5, 2012·Parasitology Research·Fnu NagajyothiHerbert B Tanowitz
Feb 14, 2013·Parasitology Research·Shankar MukherjeeHerbert B Tanowitz
Jun 1, 1988·Molecular and Biochemical Parasitology·S A MorrisM Wittner
Jan 1, 1991·Parasitology Today·S A MorrisM Wittner
Jan 1, 1994·Parasitology Today·E Rondinelli
Jul 16, 2002·International Journal for Parasitology·Huan HuangGeorge A Orr
Oct 24, 2002·International Journal for Parasitology·Linda A JelicksHerbert B Tanowitz
Jul 10, 1998·Molecular and Biochemical Parasitology·T FuruyaR Docampo
Mar 12, 1998·The Journal of Eukaryotic Microbiology·H S ZhangS A Morris
Mar 22, 2002·The Journal of Eukaryotic Microbiology·C J BacchiH B Tanowitz
Dec 22, 2005·Infection and Immunity·Ghada S HassanHerbert B Tanowitz
Mar 17, 2011·PLoS Neglected Tropical Diseases·Fnu NagajyothiHerbert B Tanowitz
May 5, 2010·The American Journal of Tropical Medicine and Hygiene·Daniel AdesseDavid C Spray
Jun 12, 1999·Endothelium : Journal of Endothelial Cell Research·H B TanowitzG J Christ
Dec 11, 2007·Microbes and Infection·Daniel AdesseDavid C Spray
Jan 1, 1992·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·H B TanowitzM Wittner
Mar 1, 1992·Experimental Parasitology·G A OrrM Wittner
Dec 3, 2014·Microbes and Infection·Shankar MukherjeeHerbert B Tanowitz
Aug 1, 1987·Experimental Parasitology·H B TanowitzM Wittner
Dec 1, 1990·Circulation·S A MorrisJ P Bilezikian
Jun 10, 2000·The Journal of Eukaryotic Microbiology·M C PereiraM N de Meirelles
Aug 1, 1994·Journal of Cardiovascular Electrophysiology·A C de CarvalhoD C Spray
Oct 1, 1992·Clinical Microbiology Reviews·H B TanowitzM Wittner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.