PMID: 9531445Apr 8, 1998Paper

Inhibition of muscle sympathetic outflow following transcranial cortical stimulation

Journal of the Autonomic Nervous System
V G MacefieldB Gunnar Wallin

Abstract

The possible contribution of cerebral cortical activity to sympathetic outflow to the muscle vascular bed was assessed in normal human subjects. Muscle sympathetic activity was recorded from motor fascicles of the peroneal nerve in 8 subjects while transcranial magnetic stimulation was applied over the vertex, or unilaterally over the hand area of cortex. By triggering the cortical stimulus from the R-wave of the ECG and introducing delays of 0-600 ms between the trigger and the stimulus, we found that a single cortical stimulus delayed by 200-400 ms caused a pronounced inhibition of one pulse-synchronous sympathetic burst. Stimulation over the vertex was more effective than stimulation over the hand area of cortex. In addition to this inhibition of muscle sympathetic outflow, brain stimulation caused an increase in cutaneous sympathetic activity, both sudomotor (sweating) and vasoconstrictor (decrease in skin blood flow). We suggest that the cerebral cortex may normally suppress muscle sympathetic outflow and speculate that lesions that interrupt this source of inhibition (such as those caused by stroke) may result in an augmented muscle sympathetic outflow.

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Citations

Nov 26, 2005·Experimental Brain Research·Andrei VoustianioukBernard Cohen
Nov 30, 2010·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Roger J PaxtonChristopher Bell
Sep 25, 2009·Medical Hypotheses·F CogiamanianA Priori
Oct 1, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Derek N EderB Gunnar Wallin
Mar 1, 2003·Acta Physiologica Scandinavica·B Gunnar WallinM Elam
Nov 26, 2004·Psychophysiology·David McIntyreDouglas Carroll
Jan 8, 2013·Neurophysiologie clinique = Clinical neurophysiology·E JørumE Dietrichs
May 21, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Pedro SchestatskyFelipe Fregni
Oct 8, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J W HamnerJ Andrew Taylor
Oct 3, 2002·The Journal of Physiology·Vincenzo DonadioB Gunnar Wallin
Oct 3, 2002·The Journal of Physiology·Vincenzo DonadioB Gunnar Wallin
Dec 30, 2006·Journal of Applied Physiology·Nathan T KuipersChester A Ray
Jan 21, 2000·Journal of Applied Physiology·D H SilberV E Amassian
Dec 19, 2020·Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association·Manda L Keller-RossBernadette T Gillick
Jan 11, 2020·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Tasha PoppaChris Baeken
Aug 12, 2021·Clinical Neurophysiology Practice·Daniel P ChantigianManda L Keller-Ross

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