Inhibition of mycoplasma pneumoniae hemadsorption and adherence to respiratory epithelium by antibodies to a membrane protein.

Infection and Immunity
D C Krause, J B Baseman

Abstract

Antiserum and purified immunoglobulin directed against Mycoplasma pneumoniae membrane protein P1 were examined for their influence on mycoplasma viability, metabolism, and cytadsorption. Anti-P1 immunoglobulin inhibited adherence of M. pneumoniae to hamster tracheal rings in vitro by up to 80% and inhibited hemadsorption by greater than 90%. Cytadsorption was also inhibited by anti-P1 Fab fragments. Anti-P1 antibodies had no effect on M. pneumoniae viability or metabolism. The data indicate that anti-P1 antibody obstructs the interaction of M. pneumoniae adhesin P1 with its host receptors.

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Citations

Oct 19, 2004·Clinical Microbiology Reviews·Ken B Waites, Deborah F Talkington
Feb 3, 2009·Molecular Microbiology·Jason M Cloward, Duncan C Krause
Mar 5, 2016·Frontiers in Microbiology·Mitchell F Balish, Steven L Distelhorst
May 22, 2010·Molecular Microbiology·Jason M Cloward, Duncan C Krause
Feb 10, 2016·Frontiers in Microbiology·Roger Dumke, Enno Jacobs
Jan 1, 1996·Annual Review of Microbiology·K Dybvig, L L Voelker
May 26, 2017·Clinical Microbiology Reviews·Ken B WaitesT Prescott Atkinson
Sep 15, 2005·Journal of Bacteriology·Benjamin M HasselbringDuncan C Krause
Jan 1, 1992·Microbiology and Immunology·M YayoshiM Yoshioka
Aug 26, 2020·Infection and Immunity·Caitlin R WilliamsDuncan C Krause
Apr 1, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Jasna Rodman BerlotDarja Keše
Jan 28, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yoshitaka NakamuraKazunobu Ouchi
Jul 1, 1986·Infection and Immunity·L B TrevinoJ B Baseman
Aug 1, 1986·Infection and Immunity·J Morrison-PlummerJ B Baseman
Aug 1, 1985·Infection and Immunity·L R WashburnL K Roberts
Sep 1, 1992·Infection and Immunity·P F MarkhamK G Whithear
Mar 1, 1988·Infection and Immunity·Y Y Chen, D C Krause
Aug 1, 1988·Infection and Immunity·D C Krause, Y Y Chen
May 14, 2021·Journal of Clinical Microbiology·Jasna Rodman BerlotDarja Keše
Aug 1, 1990·Infection and Immunity·C J SuJ B Baseman
Jan 1, 1984·Annales de microbiologie·I KahaneA Reisch-Saada

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