Inhibition of N-,P/Q- and other types of Ca2+ channels in rat hippocampal nerve terminals by the adenosine A1 receptor

European Journal of Pharmacology
A F AmbrósioC M Carvalho

Abstract

The effects of the adenosine A1 receptor agonist, N6-cyclopentyladenosine (CPA), on both the increase in intracellular free Ca2+ concentration ([Ca2+]i) and on the release of endogenous glutamate in rat hippocampal synaptosomes were studied. The inhibitory effect of CPA on the increase in [Ca2+]i stimulated with 4-aminopyridine was neutralized by the adenosine A1 receptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX). The inhibitory effect of CPA was greater in synaptosomes from the CA1 subregion than in whole hippocampal synaptosomes. The inhibitory effects of both CPA and of the Ca2+ channel blockers, omega-conotoxin GVIA, omega-conotoxin MVIIC or omega-conotoxin GVIA plus omega-conotoxin MVIIC, were greater than those caused by the Ca2+ channel blockers. The release of endogenous glutamate was inhibited by 41% by CPA. The inhibition observed when CPA and omega-conotoxin GVIA or CPA and omega-conotoxin MVIIC were present was also greater than the inhibition by the Ca2+ channel blockers alone. The presence of both omega-conotoxin GVIA and omega-conotoxin MVIIC did not completely inhibit the release of glutamate, and CPA significantly enhanced this inhibition. The membrane potential and the accumulation of [3H]tetraphe...Continue Reading

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Citations

Dec 1, 2001·Pharmacology & Therapeutics·R Tabrizchi, S Bedi
Apr 13, 2000·Neuropharmacology·R A Cunha, J A Ribeiro
Feb 24, 2015·The European Journal of Neuroscience·Francisco Q GonçalvesDaniel Rial
Jul 19, 2011·Alcoholism, Clinical and Experimental Research·Tracy R Butler, Mark A Prendergast
Dec 15, 2010·Biochimica Et Biophysica Acta·Catarina V GomesRodrigo A Cunha
Jul 2, 2016·Journal of Neurochemistry·Rodrigo A Cunha
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C SgadariB Ensoli
Dec 26, 2001·The Journal of Experimental Zoology·M H Schweitzer, C L Marshall
Dec 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Joana I GomesSandra H Vaz
Jan 6, 2021·International Journal of Molecular Sciences·Jeroen SpanogheRobrecht Raedt
Feb 29, 2020·Pharmacology & Therapeutics·Ana Raquel SantiagoAntónio Francisco Ambrósio
Feb 20, 2021·Pharmacology & Therapeutics·Aleksandra SzopaPiotr Wlaź
Sep 29, 2009·European Journal of Pharmacology·André SerpaAna M Sebastião

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