Inhibition of Na+-H+ exchange by cariporide reduces inflammation and heart failure in rabbits with myocardial infarction

British Journal of Pharmacology
Katrin RungwerthHartmut Ruetten

Abstract

The aim of this study was to assess the effects of the Na+-H+ exchange inhibitor cariporide on left ventricular (LV) morphology and function as well as inflammation in rabbits with heart failure. Rabbits with myocardial infarction (MI) and sham controls were randomized to receive either standard chow or chow supplemented with cariporide for 9 weeks. LV morphology was determined by echocardiography. LV systolic and diastolic function was assessed under load-dependent and -independent conditions by analysis of LV pressure-volume loops using piezo-electric crystals. Plasma concentrations of C-reactive protein and aldosterone were measured. Rabbits with MI developed LV dilatation that was reduced by cariporide. Systolic and diastolic LV function was impaired in rabbits with MI when compared to sham, as indicated by a decreased dP/dtmax (MI: 3537 +/- 718 mmHg s(-1), sham: 5839 +/- 247 mmHg s(-1), P < 0.05), the load-independent preload recruitable stroke work (PRSW)(MI: 22 +/-7 mmHg, sham: 81 +/- 23 mmHg, P < 0.05) and a reduction in the time constant of relaxation tau (tau) (MI: 27+/-1 ms, sham: 17+/-1 ms, P < 0.05), and significantly improved by cariporide (dP/dtmax: 4586 +/- 374 mmHg s(-1), PRSW: 67 +/- 18 mmHg, tau: 20 +/- 2 ms;...Continue Reading

References

Nov 1, 1994·Journal of Cellular Physiology·R L McSwineM L Villereal
Aug 26, 1998·Pflügers Archiv : European journal of physiology·J R SchwarkM Hropot
Oct 9, 1998·Clinical and Experimental Hypertension : CHE·W LinzW Scholz
Jul 29, 1999·Journal of Molecular and Cellular Cardiology·Y Hayasaki-KajiwaraM Nakajima
Jul 30, 1999·American Heart Journal·L Bolognese, G Cerisano
Aug 10, 2000·Journal of the American College of Cardiology·H YokoyamaM Avkiran
Sep 29, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·T KubotaD M McNamara
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·K KusumotoM Karmazyn
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R HattoriH Imamura
May 18, 2001·Current Opinion in Cardiology·M Tendera, A Ochala
Dec 1, 2001·Anesthesia and Analgesia·M RedlinA R Pries
Mar 30, 2002·Cardiovascular Research·María C Camilión de HurtadoHoracio E Cingolani
May 17, 2002·Current Opinion in Cardiology·Meeney Dhir, Sherif F Nagueh
May 30, 2002·European Journal of Heart Failure·J L Alonso-MartínezC González-Arencibia
Dec 20, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Ling ChenMorris Karmazyn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.