Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal

Biochemistry
Kenneth M HumphriesLuke I Szweda

Abstract

During the progression of certain degenerative conditions, including myocardial ischemia-reperfusion injury, mitochondria are a source of increased free-radical generation and exhibit declines in respiratory function(s). It has therefore been suggested that oxidative damage to mitochondrial components plays a critical role in the pathology of these processes. Polyunsaturated fatty acids of membrane lipids are prime molecular targets of free-radical damage. A major product of lipid peroxidation, 4-hydroxy-2-nonenal (HNE), is highly cytotoxic and can readily react with and damage protein. In this study, the effects of HNE on intact cardiac mitochondria were investigated to gain insight into potential mechanisms by which free radicals mediate mitochondrial dysfunction. Exposure of mitochondria to micromolar concentrations of HNE caused rapid declines in NADH-linked but not succinate-linked state 3 and uncoupled respiration. The activity of complex I was unaffected by HNE under the conditions of our experiments. Loss of respiratory activity reflected the inability of HNE-treated mitochondria to meet NADH demand during maximum rates of O2 consumption. HNE exerted its effects on intact mitochondria by inactivating alpha-ketoglutarate...Continue Reading

References

Mar 15, 1978·European Journal of Biochemistry·H Sies, K M Moss
Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Jan 16, 1978·European Journal of Biochemistry·H Nohl, D Hegner
Oct 1, 1978·European Journal of Biochemistry·H NohlD Hegner
Jun 1, 1991·The Journal of Clinical Investigation·G AmbrosioM Chiariello
Jan 1, 1991·Free Radical Biology & Medicine·H EsterbauerH Zollner
Jun 1, 1990·The Biochemical Journal·R Moreno-SánchezR G Hansford
Dec 15, 1981·The Biochemical Journal·G J CooneyE A Newsholme
Jul 1, 1995·Free Radical Biology & Medicine·L Tsai, E A Sokoloski
Oct 11, 1993·FEBS Letters·E EstornellG Lenaz

❮ Previous
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Citations

Dec 18, 2001·Journal of Neuroscience Research·L C ParkG E Gibson
Jan 16, 2004·Experimental Gerontology·Vadim V DavydovAnatoly I Bozhkov
Jul 28, 2004·Journal of the American Society for Mass Spectrometry·Amanda L IsomVictor Darley-Usmar
Jun 6, 2000·Brain Research. Molecular Brain Research·N R SimsE Zaidan
Feb 17, 2000·Neurochemistry International·G E GibsonN Y Calingasan
Apr 24, 2001·Free Radical Biology & Medicine·L G KorotchkinaM S Patel
Jul 4, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Edward G Lakatta, Steven J Sollott
Aug 30, 2002·The International Journal of Biochemistry & Cell Biology·Olivier ToussaintFlorence Chainiaux
Sep 21, 2011·Chemical Reviews·Francisco J SchopferBruce A Freeman
Oct 26, 2005·Biochemical Society Transactions·J W ZmijewskiV M Darley-Usmar
Aug 10, 2000·The British Journal of Surgery·R AnupK A Balasubramanian
Sep 6, 2000·Clinical and Experimental Pharmacology & Physiology·S Pepe
Jan 5, 2000·Kidney International·J H DominguezR Peterson
Jun 30, 2007·Antioxidants & Redox Signaling·Gerd Schmitz, Margot Grandl
Feb 4, 2009·Antioxidants & Redox Signaling·David F Stowe, Amadou K S Camara
Feb 23, 2012·Antioxidants & Redox Signaling·Ashlee N HigdonVictor M Darley-Usmar
Apr 14, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jan J KaczorJerzy Popinigis
Dec 18, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Richard M LoPachinTerrence Gavin
Nov 27, 2002·Journal of Cardiovascular Pharmacology·Robert HalmosiKalman Toth
Oct 27, 2004·Journal of Cardiovascular Pharmacology·Amy C Nulton-PerssonHesham A Sadek
Dec 3, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Laszlo Tretter, Vera Adam-Vizi
Feb 15, 2000·Annals of the New York Academy of Sciences·K F Sheu, J P Blass
Feb 15, 2000·Annals of the New York Academy of Sciences·L P ReaganB S McEwen
Aug 7, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G S SupinskiL A Callahan
Jul 5, 2005·American Journal of Respiratory and Critical Care Medicine·Leigh A Callahan, Gerald S Supinski
Mar 4, 2006·American Journal of Respiratory and Critical Care Medicine·Gerald S Supinski, Leigh A Callahan
Oct 9, 2008·BMC Biotechnology·Linghua QiuZuoshang Xu
Feb 8, 2011·Journal of Clinical Biochemistry and Nutrition·Lester Packer, Enrique Cadenas
Apr 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Anne-Laure BulteauLuke I Szweda
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·D T Lucas, L I Szweda
Aug 19, 2007·Pflügers Archiv : European journal of physiology·Paola VendittiSergio Di Meo
Dec 5, 2003·Archives of Biochemistry and Biophysics·Hesham A SadekLuke I Szweda
Feb 4, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Pabla AguirreMarco T Núñez

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