Abstract
Zika virus (ZIKV) is an infectious disease that has become an important concern worldwide, it associates with neurological disorders and congenital malformations in adults, also leading to fetal intrauterine growth restriction and microcephaly during pregnancy. However, there are currently no approved vaccines or specific antiviral drugs for preventing or treating ZIKV infection. Here, we show that two FDA-approved Na+/K+-ATPase inhibitors, ouabain and digoxin, can block ZIKV infection at the replication stage by targeting Na+/K+-ATPase. Furthermore, ouabain reduced the viral burden of ZIKV in adult mice, penetrated the placental barrier to enter fetal tissues, and protected fetal mice from ZIKV infection-induced microcephaly in a pregnant mouse model. Thus, ouabain has therapeutic potential for ZIKV.
References
Dec 4, 2004·Nature Medicine·John S MackenzieLyle R Petersen
Mar 21, 2008·Antiviral Research·Chun-Ting SuSui-Yuan Chang
Dec 17, 2009·The Journal of General Virology·Chun-Jung ChenJian-Hong Chen
Jun 29, 2012·Cardiovascular Research·Sanda DespaDonald M Bers
Jul 11, 2012·Antimicrobial Agents and Chemotherapy·Arun KapoorRavit Arav-Boger
Jun 14, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ian J EdwardsJim Deuchars
Jun 7, 2014·Genome Announcements·Cécile BarontiXavier de Lamballerie
Feb 6, 2015·Journal of Virology·Christine BurkardCornelis A M de Haan
Mar 8, 2016·Lancet·Van-Mai Cao-LormeauFrédéric Ghawché
Mar 31, 2016·The New England Journal of Medicine·Lyle R PetersenMargaret A Honein
May 18, 2016·Cell Stem Cell·Cui LiZhiheng Xu
May 18, 2016·Cell·Jonathan J MinerMichael S Diamond
May 24, 2016·Cell Host & Microbe·Alesha GrantAdolfo García-Sastre
May 26, 2016·MBio·Alison W AshbrookTerence S Dermody
Jul 28, 2016·Cell Reports·David W HawmanThomas E Morrison
Nov 1, 2016·EMBO Reports·Anil KumarTom C Hobman
Mar 1, 2017·Reproductive Health·Ezinne C ChibuezeOlufemi T Oladapo
Oct 13, 2017·The Journal of General Virology·Margit MutsoAndres Merits
Nov 22, 2017·Nature Microbiology·Kellie A JuradoAkiko Iwasaki
Feb 21, 2018·PLoS Pathogens·Masaharu IwasakiJuan C de la Torre
Aug 21, 2020·Antimicrobial Agents and Chemotherapy·Yan GuoFupin Hu
Citations
Mar 16, 2021·Frontiers in Physiology·Michele MartinsMagno Junqueira
Mar 24, 2021·Antimicrobial Agents and Chemotherapy·Minmin ZhouWei Wang
May 14, 2021·Journal of Virology·Xiaoying JiaWei Wang