Inhibition of neointima hyperplasia by the combined therapy of linagliptin and metformin via AMPK/Nox4 signaling in diabetic rats

Free Radical Biology & Medicine
Wen-Xu ZhangMing Xu

Abstract

Neointima hyperplasia is the pathological basis of atherosclerosis and restenosis which have been associated with diabetes mellitus (DM). It is controversial for linagliptin and metformin to protect against vascular neointimal hyperplasia caused by DM. Given the combined therapy of linagliptin and metformin in clinical practice, we investigated whether the combination therapy inhibited neointimal hyperplasia in the carotid artery in diabetic rats. Neointima hyperplasia in the carotid artery was induced by balloon-injury in the rats fed with high fat diet (HFD) combined with low dose streptozotocin (STZ) administration. In vitro, vascular smooth muscle cells (VSMCs) were incubated with high glucose (HG, 30 mM) and the proliferation, migration, apoptosis and collagen deposition were analyzed in VSMCs. We found that the combined therapy, not the monotherapy of linagliptin and metformin significantly inhibited the neointima hyperplasia and improved the endothelium-independent contraction in the balloon-injured cardia artery of diabetic rats, which was associated with the inhibition of superoxide (O2-.) production in the cardia artery. In vitro, HG-induced VSMC remodeling was shown as the remarkable upregulation of PCNA, collagan1, ...Continue Reading

References

Dec 18, 2002·Methods in Cell Science : an Official Journal of the Society for in Vitro Biology·J L RayM Benson
Dec 6, 2006·The New England Journal of Medicine·Steven E KahnUNKNOWN ADOPT Study Group
Apr 28, 2007·Free Radical Biology & Medicine·Alejandra San MartinFederico Leighton
Mar 19, 2008·Clinical and Experimental Pharmacology & Physiology·Eduardo MeaneyGuillermo Ceballos
Oct 24, 2009·Journal of Vascular Research·Anthony Wayne OrrBrian R Wamhoff
Sep 30, 2010·Journal of Cellular and Molecular Medicine·Qiang Xu, Liang-Yi Si
Jan 11, 2011·Biochemical and Biophysical Research Communications·Hiromasa GotoHirotaka Watada
Dec 12, 2012·European Journal of Pharmacology·Yoichiro HirataMasataka Sata
Apr 23, 2013·Antioxidants & Redox Signaling·Augusto C Montezano, Rhian M Touyz
Jan 1, 2014·British Journal of Pharmacology·Gnanapragasam ArunachalamChris R Triggle
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·David PreissNaveed Sattar
Jun 16, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Annayya R AroorVincent G DeMarco
Nov 20, 2014·Cardiovascular Diabetology·Yuichi TerawakiToshihiko Yanase
Dec 21, 2014·Journal of the American Heart Association·Farshad ForouzandehR Wayne Alexander
May 27, 2015·CNS Neuroscience & Therapeutics·Edy KorneliusChien-Ning Huang
Nov 20, 2015·Journal of Molecular and Cellular Cardiology·Xiaoyong TongRichard A Cohen
Feb 20, 2016·Circulation Research·Martin R BennettGary K Owens
Aug 5, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ting HeJinghong Zhao
Sep 30, 2016·Postgraduate Medicine·Stuart A RossMaximilian von Eynatten
Nov 23, 2016·Journal of Cardiovascular Pharmacology·Linnea ErikssonAnton Razuvaev
Mar 10, 2017·Free Radical Biology & Medicine·Yao Li, Patrick J Pagano
May 10, 2017·Circulation·Ronald B GoldbergUNKNOWN Diabetes Prevention Program Research Group
Jan 7, 2018·Biochemical and Biophysical Research Communications·Yun ZhaoXin Jin
Oct 12, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xing-Rong AnMing Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis