Inhibition of neuronal nitric oxide synthase increases adrenalectomy-induced granule cell death in the rat dentate gyrus

Brain Research
Chan ParkYoungbuhm Huh

Abstract

Recent studies have shown that the expression of neuronal nitric oxide synthase (NOS) mRNA is increased after adrenalectomy (ADX). However, the role of increased NO production after ADX in the dentate gyrus is unknown. In this study, the relationship between NO inhibition and apoptosis in the dentate gyrus after ADX was examined. 7-Nitroindazole (7-NI; 30 mg/kg, i.p.), a selective inhibitor of neuronal NOS, was injected 1 day before ADX and subsequently once every 24 h. Then 4 days after ADX, dentate granule cell death was evaluated using silver impregnation and Nissl staining methods. Inhibition of neuronal NOS by 7-NI increased the number of dying granule cells approximately 4-fold in the dentate gyrus of the ADX rats, compared to vehicle-injected ADX controls. These results suggest that increased NO production after ADX may play an endogenous neuroprotective role in the dentate gyrus.

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Citations

May 1, 2007·European Archives of Psychiatry and Clinical Neuroscience·Andreas ReifKlaus-Peter Lesch
May 5, 2011·Journal of Biomedicine & Biotechnology·Simon C SpanswickRobert J Sutherland
Sep 22, 2012·Stem Cells International·Bruno P CarreiraInês M Araújo
Jun 26, 2014·British Journal of Pharmacology·A I SantosI M Araújo
Aug 13, 2004·The European Journal of Neuroscience·Andreas ReifKlaus-Peter Lesch
Nov 18, 2005·Brain Research. Brain Research Reviews·Antonio CárdenasIgnacio Lizasoain

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis