Inhibition of neuronal uptake reduces the presynaptic effects of clonidine but not of alpha-methylnoradrenaline on the stimulation-evoked release of 3H-noradrenaline from rat occipital cortex slices

European Journal of Pharmacology
F PelayoS Z Langer

Abstract

The iminoimidazolidine clonidine reduced concentration-dependently the release of 3H-noradrenaline evoked by electrical stimulation from the rate cerebral cortex. Exposure to the neuronal uptake inhibitors cocaine (10 micro M), desipramine (0.1 to 1 micro M) and amphetamine (1 micro M) significantly increased the stimulation-evoked overflow of tritium. These uptake inhibitors antagonized the effects of clonidine on stimulation evoked 3H-noradrenaline release but failed to modify the inhibition induced by the catecholamine alpha-methylnoradrenaline. Inhibition of monoamine oxidase by preincubation of cerebral cortex slices with 0.5 mM pargyline significantly increased the stimulation-evoked overflow of tritium, but clonidine was as effective as in the controls in inhibiting 3H-noradrenaline overflow. The antagonism by desipramine of the clonidine-induced inhibition of neurotransmission could not be attributed to a blockade of presynaptic alpha-adrenoceptors because: (1) the facilitating effect of phentolamine on 3H-noradrenaline overflow was not modified in the presence of desipramine; (2) the magnitude of the inhibition of the stimulation-evoked 3H-noradrenaline release elicited by alpha-methylnoradrenaline was the same in the ...Continue Reading

References

Nov 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·A T Sullivan, G M Drew
Dec 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·M L Fiszman, F J Stefano
Jan 1, 1991·Psychopharmacology·M E Reith, C T Fischette
Dec 5, 1980·European Journal of Pharmacology·M F Sugrue
Mar 5, 1981·European Journal of Pharmacology·L HedlerK Starke
Oct 8, 1999·Journal of Autonomic Pharmacology·P ThainaM J Rand

Citations

Nov 3, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·K StarkeH D Taube
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R R RuffoloP N Patil
Jun 1, 1977·The Journal of Pharmacy and Pharmacology·R R RuffoloP N Patil
Sep 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·H D TaubeE Borowski
Oct 16, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·I C MedgettM J Rand
Oct 25, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·P A Baumann, L Maître
Jun 1, 1978·British Journal of Pharmacology·I E Hughes
Aug 11, 1978·Brain Research·T M Jessell
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·L O Farnebo, B Hamberger
Apr 1, 1973·British Journal of Pharmacology·A G BlakeleyR J Summers
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·K Starke
Sep 1, 1972·British Journal of Pharmacology·M W McCulloch, D F Story
Mar 3, 1973·British Medical Journal·R H BriantC T Dollery
Jul 1, 1974·Biochemical Pharmacology·S Z Langer
Sep 1, 1968·European Journal of Pharmacology·J W Constantine, W K McShane

Related Concepts

Z-Max
Amphetamine
ratio-Desipramine
Methylnorepinephrine
Occipital Lobe
Catecholamine [EPC]
Thyramine
Uptake
Catecholamines Measurement
Synaptic Transmission

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.