Apr 1, 1976

Inhibition of Newcastle disease virus replication by 6-azauridine. II. Combination of 6-azauridine and adenine derivatives

Acta Virologica
B Rada, M Dragún

Abstract

Twenty-five metabolites (purines, pyrimidines, nucleosides and nucleosides) were tested for their simultaneous action with 6-azauridine (AzUrd) in inhibition of Newcastle disease virus (NDV) replication. With the exception of deoxyadenosine and cyclic AMP all natural adenine derivatives exerted a synergic effect with AzUrd like ATP. Glutamine in combination with AzUrd did not inhibit NDV replication. The inhibitory effect of the combination of AzUrd and adenine derivatives was reversible by guanosine, uridine and cytidine but not by orotic acid or orotidylic acid.

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Mentioned in this Paper

Newcastle disease virus
Azauridine
Purine Nucleotides
Virus Replication
Pyrimidine Nucleotides
Culture Techniques
Newcastle Disease
Zinc Orotate
Drug Augmentation
Purine Nucleosides

About this Paper

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