Inhibition of NF-κB activity in the hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by modulating cytokines and attenuating oxidative stress

Toxicology and Applied Pharmacology
Xiao-Jing YuYu-Ming Kang

Abstract

We hypothesized that chronic inhibition of NF-κB activity in the hypothalamic paraventricular nucleus (PVN) delays the progression of hypertension and attenuates cardiac hypertrophy by up-regulating anti-inflammatory cytokines, reducing pro-inflammatory cytokines (PICs), attenuating nuclear factor-κB (NF-κB) p65 and NAD(P)H oxidase in the PVN of young spontaneously hypertensive rats (SHR). Young normotensive Wistar-Kyoto (WKY) and SHR rats received bilateral PVN infusions with NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC) or vehicle for 4 weeks. SHR rats had higher mean arterial pressure and cardiac hypertrophy as indicated by increased whole heart weight/body weight ratio, whole heart weight/tibia length ratio, left ventricular weight/tibia length ratio, cardiomyocyte diameters of the left cardiac ventricle, and mRNA expressions of cardiac atrial natriuretic peptide (ANP) and beta-myosin heavy chain (β-MHC). These SHR rats had higher PVN levels of proinflammatory cytokines (PICs), reactive oxygen species (ROS), the chemokine monocyte chemoattractant protein-1 (MCP-1), NAD(P)H oxidase activity, mRNA expression of NOX-2 and NOX-4, and lower PVN IL-10, and higher plasma levels of PICs and NE, and lower plasma IL-10. PVN infu...Continue Reading

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Citations

Mar 15, 2016·Asian Pacific Journal of Tropical Medicine·Zi-Ran WangMing-Yu Luo
Jul 5, 2016·Frontiers in Physiology·Brunella F KlippelElisardo C Vasquez
Jul 28, 2016·Journal of Applied Toxicology : JAT·Fen HuangGaku Ichihara
Dec 29, 2017·The Journal of Experimental Medicine·Guodong SunZhinan Yin
Oct 5, 2018·Clinical and Experimental Hypertension : CHE·Jisheng ChenYanhua Xiong
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Jun 17, 2021·The Journal of International Medical Research·Shasha LiuWei He
Apr 1, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Abdoh TalebDing Qilong

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