Inhibition of nifedipine-induced proliferation of cultured human gingival fibroblasts by Saiko, a Chinese herbal medicine

Phytotherapy Research : PTR
Toshimi HattoriPao-Li Wang

Abstract

Saiko is predominantly contained in Saireito, a Chinese herbal medicine. The present study was conducted to determine whether or not Saiko is involved in the inhibition by Saireito of nifedipine-induced proliferation and collagen synthesis in gingival fibroblasts. Nifedipine (10 microM) significantly enhanced the proliferation starting on day 5 of the culture period. When added together with nifedipine, Saiko at concentrations of 0.05%-0.2% (w/v) dose-dependently inhibited the nifedipine-induced proliferation, and at the highest concentration tested (0.2%), Saiko inhibited the nifedipine-induced proliferation by about 40%. Moreover, Saiko (0.2%) also inhibited the normal proliferation at days 11 and 14. Sole application of nifedipine (10 microM) augmented the release of bFGF, and Saiko concentration-dependently reduced the level of bFGF in the nifedipine-containing culture medium. Nifedipine (10 microM) increased the production of type I collagen to almost twice that of the control (normal medium), and Saiko at concentrations above 0.1% significantly reduced the nifedipineinduced production of collagen. In conclusion, the present findings demonstrate that Saiko inhibited the nifedipine-induced proliferation of gingival fibrobla...Continue Reading

References

Jul 8, 2003·Nature Neuroscience·Ute BechererMartin Oheim
Jan 5, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Toshimi Hattori, Wang Pao-Li

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Citations

Dec 2, 2009·European Journal of Medical Research·T HattoriP L Wang
Apr 13, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Qi ZhangMasanori Niimi
Aug 14, 2013·Expert Opinion on Pharmacotherapy·Chenyu Huang, Rei Ogawa

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