PMID: 8583150Nov 1, 1995Paper

Inhibition of nitric oxide production increases dimethylnitrosamine-induced liver injury in rats

Journal of Hepatology
S NagaseH Nawata

Abstract

Intravascular coagulation is involved in the development of certain types of liver injury, including that induced by dimethylnitrosamine. Nitric oxide inhibits platelet aggregation and adhesion; however, its role in protecting against intravascular coagulation has not been clarified. We therefore investigated the effect of blocking the production of NO in a dimethylnitrosamine-induced liver injury model. Wistar male rats received dimethylnitrosamine (50 micrograms/kg) intraperitoneally, and were treated with N omega-nitro-L-arginine, an inhibitor of nitric oxide synthase, or N omega-nitro-D-arginine, an inactive isomer. Each arginine derivative (40 mg/kg) was injected intraperitoneally every 6 h. Twenty-four hours after dimethyl-nitrosamine administration, we observed a significant increase in the serum level of alanine aminotransferase in the N omega-nitro-L-arginine group compared with the N omega-nitro-D-arginine group. The N omega-nitro-L-arginine-treated group also exhibited a significant reduction in platelet count, a prolongation of prothrombin time, and an elevation of plasma soluble fibrin monomer complex levels. Sinusoidal congestion, intravascular coagulation, and coagulation necrosis around the central veins were pr...Continue Reading

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Citations

Mar 31, 1999·Journal of Biochemical and Molecular Toxicology·J M McMillan
Mar 31, 1999·Journal of Biochemical and Molecular Toxicology·J M McMillan
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·P Muriel, P González
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·E BattinelliJ Loscalzo
Jul 16, 2011·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·Yucel OzsoyBeyhan Ozyurt
Jan 31, 2017·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Na HuJun Wang
Jul 29, 2017·Bioscience, Biotechnology, and Biochemistry·Akika FukawaAkira Hosono

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