Inhibition of nitric oxide synthase by NG-nitro-L-arginine causes a preferential decrease in pancreatic islet blood flow in normal rats and spontaneously diabetic GK rats

Endocrinology
A M SvenssonL Jansson

Abstract

To elucidate the effect of nitric oxide (NO) on the blood flow of the pancreatic islets, the NO synthase inhibitor NG-nitro-L-arginine (N-arg; 25 mg/kg BW) was administered iv to rats 10 min before pancreatic blood flow was measured with a nonradioactive microsphere technique. In male Sprague-Dawley rats, N-arg induced a marked decrease in islet blood flow (16 +/- 4 vs. 44 +/- 8 microliters/min.g pancreas; P < 0.001) and a less pronounced decrease in whole pancreatic blood flow (0.27 +/- 0.04 vs. 0.43 +/- 0.06 ml/min.g; P < 0.05), leading to a markedly decreased fractional islet blood flow (5.5 +/- 0.9% vs. 10.3 +/- 1.3%; P < 0.02). In a second experiment, injection of D-glucose (300 mg/kg BW, iv) in male Sprague-Dawley rats induced a selective increase in islet blood flow (P < 0.05). Such an increase has previously been shown to be mediated by a vagal cholinergic mechanism. Administration of N-arg to these rats resulted in decreased pancreatic (P < 0.05), islet (P < 0.001), and fractional (P < 0.001) islet blood flow, which did not differ from those observed in normoglycemic rats after treatment with N-arg. Furthermore, we studied the mechanism behind the previously described increase in islet blood perfusion, mediated by the ...Continue Reading

Citations

Jul 15, 1997·The Journal of Clinical Investigation·M ShimabukuroR H Unger
Mar 15, 1996·Experientia·A M Svensson, L Jansson
Dec 1, 1994·Diabetes/metabolism Reviews·L Jansson
Feb 18, 2011·Langenbeck's Archives of Surgery·Leif JanssonOrjan Källskog
Nov 15, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·P-O CarlssonL Jansson
Sep 18, 2017·Journal of Endocrinological Investigation·X XuX Gao
Apr 14, 2010·International Journal of Experimental Pathology·Huw Bowen JonesRichard Jenkins
Feb 8, 2007·American Journal of Physiology. Endocrinology and Metabolism·En Yin LaiLeif Jansson
May 19, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Raju C ReddyMatthew J DiMagno
Aug 21, 2014·American Journal of Physiology. Endocrinology and Metabolism·Enyin LaiLeif Jansson
Jul 13, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael HultströmOrjan Källskog
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·A M SvenssonL Jansson
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M IwaseM Yoshinari
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P O CarlssonL Jansson
Apr 29, 2016·Upsala Journal of Medical Sciences·Leif JanssonPer-Ola Carlsson
Oct 1, 1998·The American Journal of Physiology·P O CarlssonL Jansson
Sep 1, 2009·Expert Review of Endocrinology & Metabolism·Johan OlerudPer-Ola Carlsson
Aug 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Per-Ola CarlssonLeif Jansson
Apr 16, 2013·The American Journal of Pathology·Xia ChuAndreea Barbu
Dec 1, 1995·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·F C BrunicardiD K Andersen

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