PMID: 9416733Jan 7, 1998Paper

Inhibition of nitric oxide synthase decreases anesthetic requirements of intravenous anesthetics in Xenopus laevis

Anesthesiology
P H TonnerJ Schulte am Esch

Abstract

Acute inhibition of nitric oxide synthase (NOS) has been demonstrated to reduce the anesthetic requirements of volatile anesthetics. Recent data suggest that not only volatile but also intravenous anesthetic agents interact with nitric oxide (NO) metabolism. The aim of this study was to examine the effect of NOS inhibition by nitroG-L-arginine-methyl-ester (L-NAME) on the anesthetic action of the intravenous anesthetics thiopental, propofol, and ketamine. The anesthetic potencies of thiopental, propofol, and ketamine were determined in Xenopus laevis tadpoles in the absence and presence of L-NAME. Anesthesia was defined as loss of righting reflex for 5 s. A nonlinear logistic regression curve was fitted to the data and half-maximal effective concentrations (EC50) were calculated. A second set of experiments was performed with different concentrations of L-NAME in the presence of the previously determined the EC50 of the intravenous anesthetics. The EC50s of the anesthetics thiopental, propofol, and ketamine were determined to be 25.5 +/- 2.0 microM, 1.9 +/- 0.1 microM, and 59.7 +/- 0.7 microM, respectively. The addition of L-NAME shifted the concentration-response curves to the left in a concentration-dependent manner. In the p...Continue Reading

References

Jul 1, 1992·Acta Physiologica Scandinavica·S Moncada
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Feb 1, 1991·Trends in Neurosciences·J Garthwaite
Jun 1, 1991·Anesthesia and Analgesia·J Zucker
Dec 1, 1989·Journal of Neurochemistry·J GarthwaiteM Anderton
Jan 1, 1983·British Journal of Anaesthesia·Y VulliemozL Triner
Nov 1, 1995·Anesthesia and Analgesia·R A Schroeder, P C Kuo
Nov 1, 1994·Anesthesiology·J R TobinR J Traystman
Nov 1, 1994·Neuropharmacology·M R Dzoljic, R De Vries
Mar 1, 1995·Journal of Neurocytology·J G ValtschanoffH H Schmidt
May 26, 1995·Brain Research. Developmental Brain Research·M J CroweM S Beattie
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·A SeilicovichS M McCann
Apr 1, 1993·Anesthesiology·D L TanelianM B MacIver
Sep 1, 1996·Anesthesia and Analgesia·H F Galley, N R Webster
Aug 1, 1996·Neurochemistry International·V L Dawson, T M Dawson

❮ Previous
Next ❯

Citations

Sep 16, 1999·Cellular and Molecular Life Sciences : CMLS·M D Krasowski, N L Harrison
Oct 22, 2003·Journal of the Neurological Sciences·Satoshi ShibutaTakashi Mashimo
Sep 28, 2002·Anesthesia and Analgesia·Tadanobu YasudaAkitomo Matsuki
Nov 29, 2007·Anesthesia and Analgesia·Andrea ParisPeter H Tonner
Feb 18, 2006·Pharmacology & Therapeutics·Bernd W UrbanMartin Barann
Sep 24, 2015·Pharmacological Reports : PR·Aysu H TezcanTayfun Uzbay
Dec 13, 2007·Anesthesiology·Noboru TodaYoshio Hatano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.