Inhibition of nitric oxide synthase does not block the development of sensitization to the behavioral activating effects of amphetamine

Brain Research
J StewartS Amir

Abstract

Pretreatment with the nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), a competitive blocker of NO production, did not interfere with the development of sensitization to the behavioral activating effects of amphetamine (AMPH). On five pre-exposure sessions, at 3-day intervals, rats were given two i.p. injections, either 50 mg/kg L-NAME 30 min prior to 1.5 mg/kg D-AMPH sulfate, saline and AMPH, L-NAME and saline, or saline only. L-NAME reduced the levels of activity recorded during the pre-exposure session but had no effect on the degree of sensitization shown to a challenge injection of 0.5 mg/kg AMPH given 10 days later. A separate study using in vivo microdialysis showed that pretreatment with L-NAME did not alter AMPH-stimulated dopamine release in nucleus accumbens.

Citations

Mar 30, 2010·The European Journal of Neuroscience·Leora YetnikoffCecilia Flores
Nov 22, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yotam SagiPaul Greengard
Jul 14, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephen SammutAnthony R West

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.