Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats

Brain Research
R MaggioM Riva

Abstract

We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation.

References

Nov 12, 1991·European Journal of Pharmacology·J P NowickiB Scatton

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Citations

Apr 20, 2000·European Journal of Pharmacology·G De SarroA De Sarro
May 7, 1998·European Journal of Pharmacology·C B AlexanderR D Kirkby
Jul 19, 2000·Pharmacology, Biochemistry, and Behavior·B Shi, J E Heavner
Nov 14, 1997·Neuroscience Letters·R D LeesS W D'Souza
Jan 1, 1997·Brain Research Bulletin·E DzoljicM R Dzoljic
Jun 5, 1999·Brain Research Bulletin·A R JayakumarR Jayakumar
Apr 21, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·T ArakiY Itoyama
Sep 11, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Giuseppe FerraroVittorio La Grutta
Jan 26, 2000·Journal of Neurochemistry·D HanT Nabeshima
Jan 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C MontécotE Pinard
Jul 1, 1997·Clinical and Experimental Pharmacology & Physiology·H C KimM B Wie
Sep 9, 2010·Chemical & Pharmaceutical Bulletin·Fatma Abdel-Fattah RagabAhmed Mahmoud El Kerdawy
Aug 8, 2001·Japanese Journal of Pharmacology·C Marangoz, F Bağirici
Mar 9, 2012·Neurochemical Research·Abdullah Hilmi MarangozCafer Marangoz
Feb 8, 2013·Neurochemical Research·Yasser A KhadrawyHaitham S Mohammed
Jul 11, 2008·Critical Reviews in Toxicology·Edward J Calabrese
Feb 9, 2005·Neuroscience Letters·Luiz Fernando Freire RoyesCarlos Fernando Mello
Jun 24, 2004·Brain Research·Helena ParfenovaCharles W Leffler
Aug 2, 2008·Seizure : the Journal of the British Epilepsy Association·T KamidaH Kobayashi
Jan 1, 1997·Nitric Oxide : Biology and Chemistry·E TalaveraM Condés-Lara
Aug 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E A Del-BelN Garcia-Cairasco
Nov 6, 2004·The International Journal of Neuroscience·B E McKay, M A Persinger
Aug 22, 2002·The International Journal of Neuroscience·Ersin O KoyluSakire Pogun
May 28, 2020·The European Journal of Neuroscience·César Augusto BrüningCristina Wayne Nogueira

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