Inhibition of nitric oxide synthase during hemorrhagic shock increases hepatic injury

Shock
Brian G HarbrechtT R Billiar

Abstract

The function of nitric oxide (NO) in hemorrhagic shock is controversial. Increased NO synthesis has been temporally correlated with severe shock and has been associated with vascular hyporeactivity to vasoconstrictor agents in isolated vascular rings. Its role in local tissue perfusion, however, is unknown. We studied the role of NO in shock-induced hepatic injury in a rodent model of decompensated hemorrhagic shock by inhibiting its synthesis with Nw-nitro-L-arginine methyl ester (L-NAME). L-NAME infusion (5 micrograms/kg/min) increased the shock-induced hepatic injury and this effect was reversible with L-arginine. L-NAME had only transient effects on systemic mean arterial blood pressure, which quickly returned to pre-L-NAME levels. We conclude that NO synthesis serves a protective function in preventing shock-induced hepatic injury and we postulate that this effect may be due to modulation of the local hepatic circulation.

Citations

Oct 31, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J YangJ Norman
May 1, 1997·Disease-a-month : DM·R G KilbournC Szabó
Sep 13, 2003·Resuscitation·Michelle McDonaldChristoph Thiemermann
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T InoueT Okumura
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gautam P YagnikDavid A Geller
Apr 4, 1998·The Journal of Experimental Medicine·C HierholzerD J Tweardy
Jan 5, 2001·Annals of Surgery·P O Hasselgren, J E Fischer
Apr 12, 2003·Shock·Isaiah R TurnbullTimothy G Buchman
Jul 17, 2004·Shock·Brian G HarbrechtBaochun Zhang
Oct 28, 1998·Environmental Health Perspectives·N S Shah, T R Billiar
Aug 27, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Menachem M WeinerGregory W Fischer
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M G Clemens
Apr 24, 2012·Clinics and Research in Hepatology and Gastroenterology·Verena Keitel, Dieter Häussinger
Oct 16, 2007·Nitric Oxide : Biology and Chemistry·Katsuji TokuharaTadayoshi Okumura
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Verena KeitelRalf Kubitz
Sep 8, 2004·Nitric Oxide : Biology and Chemistry·Shigeru TeshimaTadayoshi Okumura
Aug 28, 2014·Journal of Cellular Biochemistry·Jaganathan LakshmananBrian G Harbrecht
Oct 14, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Qilin Gu, Zongbin Cui
Oct 29, 1998·The Journal of Surgical Research·T M FruchtermanR N Garrison
Jul 15, 1997·The Journal of Surgical Research·P J DownardR N Garrison
Feb 16, 1999·The Journal of Laboratory and Clinical Medicine·A GulatiA P Sen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.