Inhibition of nitric oxide synthase partially attenuates alterations in the blood-cerebrospinal fluid barrier during experimental meningitis in the rat

European Journal of Pharmacology
K M Boje

Abstract

The permeability of the blood-cerebrospinal fluid (blood-CSF) barrier is increased upon exposure to lipopolysaccharides during bacterial meningitis. Lipopolysaccharides induce nitric oxide (NO) synthase in a variety of cells. Increased meningeal NO production and blood-CSF barrier permeability were observed in a rat model of meningitis. Administration of aminoguanidine, an inhibitor of NO synthase, blocked meningeal NO production and significantly attenuated permeability changes in the blood-CSF barrier. It is hypothesized that pathological production of NO may contribute to the disruption of the blood-CSF barrier during meningitis.

References

Sep 1, 1976·Experimental Neurology·S I Rapoport
Sep 17, 1992·The New England Journal of Medicine·V Quagliarello, W M Scheld
Mar 16, 1993·European Journal of Pharmacology·T P MiskoM G Currie
Sep 23, 1994·Cell·H H Schmidt, U Walter
Feb 15, 1994·Annals of Internal Medicine·J J VisserK Hoekman

❮ Previous
Next ❯

Citations

Oct 6, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R PaulH W Pfister
May 31, 2001·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·W G Mayhan
Jun 27, 2007·Infection and Immunity·Olaf HoffmannJoerg R Weber
Jul 2, 1999·Microvascular Research·O Z ChiH R Weiss
Jan 12, 2007·Progress in Neurobiology·Matthias KleinHans-Walter Pfister
Jul 24, 2013·Antimicrobial Agents and Chemotherapy·Tobias HögenMatthias Klein
Aug 1, 2002·Current Protocols in Pharmacology·Kathleen M K Boje
Mar 28, 1998·Scandinavian Journal of Clinical and Laboratory Investigation·H TsukaharaM Mayumi
Nov 27, 1999·Scandinavian Journal of Infectious Diseases·G UysalH Uysal
Nov 26, 2010·Synapse·Sigal Liraz-ZaltsmanAnat Biegon
Mar 1, 1997·Annals of Saudi Medicine·S L Kaplan
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad
Aug 13, 1999·Nitric Oxide : Biology and Chemistry·T KomatsuC S Reiss

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.